A novel third-generation TSH receptor antibody (TRAb) enzyme-linked immunosorbent assay based on a murine monoclonal TSH receptor-binding antibody
Sign Up to like & getrecommendations! Published in 2018 at "Immunologic Research"
DOI: 10.1007/s12026-018-9062-z
Abstract: TSH receptor (TSHR) autoantibody (TRAb) is the serological hallmark of Graves’ disease (GD). Third-generation enzyme-linked immunosorbent assays (ELISAs) using monoclonal TRAbs instead of TSH have been found useful for TRAb analysis recently. For the first… read more here.
Keywords: generation; tsh receptor; antibody; third generation ... See more keywords
Teprotumumab: a new avenue for the management of moderate-to-severe and active Graves’ orbitopathy?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-017-0717-8
Abstract: discrepancy [8],because of these conflicting results, the role of rituximab for moderate-to-severe and active GO remains to be defined in larger, multicenter RCTs [9]. The recent guidelines published by the European Thyroid Association/ European Group… read more here.
Keywords: graves orbitopathy; moderate severe; receptor; active graves ... See more keywords
TSH receptor specific monoclonal autoantibody K1-70TM targeting of the TSH receptor in subjects with Graves' disease and Graves' orbitopathy - results from a phase I clinical trial: Conclusions.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical endocrinology"
DOI: 10.1111/cen.14681
Abstract: OBJECTIVES In Graves' disease (GD), autoantibodies to the thyroid stimulating hormone receptor (TSHR) cause hyperthyroidism. The condition is often associated with eye signs including proptosis, oedema, and diplopia (collectively termed Graves' orbitopathy (GO)). The safety… read more here.
Keywords: graves disease; graves orbitopathy; phase clinical; tsh receptor ... See more keywords
Modeling TSH Receptor Dimerization at the Transmembrane Domain.
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DOI: 10.1210/endocr/bqac168
Abstract: Biophysical studies have established that the TSH receptor (TSHR) undergoes post translational modifications including dimerization. Following our earlier simulation of a TSH receptor - transmembrane domain (TMD) monomer (called TSHR-TMD-TRIO) we have now proceeded with… read more here.
Keywords: transmembrane domain; tshr; dimerization; tsh receptor ... See more keywords
Characteristics of specific immunological indicators in patients with postoperative relapse of Graves’ disease
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Endocrinology"
DOI: 10.22141/2224-0721.14.1.2018.127095
Abstract: Background. Activity of autoimmune processes had a leading role in the development of relapse of hyperthyroidism. Level of thyroid-stimulating hormone (TSH) receptor antibodies is a basic factor that predetermines the relapse and can be used… read more here.
Keywords: patients postoperative; relapse; graves disease; postoperative relapse ... See more keywords
Commentary: Brief report - Monoclonal antibodies illustrate the difficulties in measuring blocking TSH receptor antibodies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1060280
Abstract: A Commentary on Brief report - Monoclonal antibodies illustrate the dif fi culties in measuring blocking TSH receptor antibodies the dif fi culties in measuring blocking TSH receptor read more here.
Keywords: commentary brief; brief report; blocking tsh; measuring blocking ... See more keywords
The Mysterious Universe of the TSH Receptor
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DOI: 10.3389/fendo.2022.944715
Abstract: The thyroid-stimulating hormone receptor (TSH-R) is predominantly expressed in the basolateral membrane of thyrocytes, where it stimulates almost every aspect of their metabolism. Several extrathyroidal locations of the receptor have been found including: the pituitary,… read more here.
Keywords: mysterious universe; tsh receptor; receptor; universe tsh ... See more keywords
Proximity ligation assay to study TSH receptor homodimerization and crosstalk with IGF-1 receptors in human thyroid cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.989626
Abstract: Proximity ligation assay (PLA) is a methodology that permits detection of protein-protein closeness, that is, proteins that are within 40 nanometers of each other, in cells or tissues at endogenous protein levels or after exogenous… read more here.
Keywords: receptor homodimerization; ligation assay; proximity ligation; tsh receptor ... See more keywords
Clinical utility of TSH receptor antibody levels in Graves’ orbitopathy: a comparison of two TSH receptor antibody immunoassays
Sign Up to like & getrecommendations! Published in 2018 at "Central-European Journal of Immunology"
DOI: 10.5114/ceji.2018.80224
Abstract: Introduction Thyroid stimulating hormone (TSH) receptor antibodies (TRAB) play a role in the development of Graves’ orbitopathy (GO), and measurements of the TRAB level may be helpful in monitoring GO treatment. Aim of the study… read more here.
Keywords: receptor antibody; trab; antibody; tsh receptor ... See more keywords