A novel third-generation TSH receptor antibody (TRAb) enzyme-linked immunosorbent assay based on a murine monoclonal TSH receptor-binding antibody
Sign Up to like & getrecommendations! Published in 2018 at "Immunologic Research"
DOI: 10.1007/s12026-018-9062-z
Abstract: TSH receptor (TSHR) autoantibody (TRAb) is the serological hallmark of Graves’ disease (GD). Third-generation enzyme-linked immunosorbent assays (ELISAs) using monoclonal TRAbs instead of TSH have been found useful for TRAb analysis recently. For the first… read more here.
Keywords: generation; tsh receptor; antibody; third generation ... See more keywords
Teprotumumab: a new avenue for the management of moderate-to-severe and active Graves’ orbitopathy?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-017-0717-8
Abstract: discrepancy [8],because of these conflicting results, the role of rituximab for moderate-to-severe and active GO remains to be defined in larger, multicenter RCTs [9]. The recent guidelines published by the European Thyroid Association/ European Group… read more here.
Keywords: graves orbitopathy; moderate severe; receptor; active graves ... See more keywords
TSH receptor specific monoclonal autoantibody K1-70TM targeting of the TSH receptor in subjects with Graves' disease and Graves' orbitopathy - results from a phase I clinical trial: Conclusions.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical endocrinology"
DOI: 10.1111/cen.14681
Abstract: OBJECTIVES In Graves' disease (GD), autoantibodies to the thyroid stimulating hormone receptor (TSHR) cause hyperthyroidism. The condition is often associated with eye signs including proptosis, oedema, and diplopia (collectively termed Graves' orbitopathy (GO)). The safety… read more here.
Keywords: graves disease; graves orbitopathy; phase clinical; tsh receptor ... See more keywords
Modeling TSH Receptor Dimerization at the Transmembrane Domain.
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DOI: 10.1210/endocr/bqac168
Abstract: Biophysical studies have established that the TSH receptor (TSHR) undergoes post translational modifications including dimerization. Following our earlier simulation of a TSH receptor - transmembrane domain (TMD) monomer (called TSHR-TMD-TRIO) we have now proceeded with… read more here.
Keywords: transmembrane domain; tshr; dimerization; tsh receptor ... See more keywords
The TSH Receptor Antibody Reactome Contributes to Retro-Orbital Inflammation.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae182
Abstract: The thyroid eye disease (TED) of Graves disease is associated with high titers of stimulating TSH receptor antibodies, retro-orbital inflammation, fibroblast release of cytokines and chemokines, and adipogenesis, which in turn leads to proptosis, muscle… read more here.
Keywords: receptor; tshr; tsh receptor; orbital inflammation ... See more keywords
Safety, pharmacokinetics, and potential benefits of TSH-receptor-specific monoclonal autoantibody K1-70TM in Japanese Graves’ disease patients: results of a phase 1 trial
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DOI: 10.1507/endocrj.ej25-0043
Abstract: This phase 1 dose-escalation study evaluated the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of K1-70TM, a TSH-receptor-specific monoclonal autoantibody that inhibits ligand binding and receptor activation, in Japanese Graves’ disease (GD) patients. Twelve patients… read more here.
Keywords: receptor; monoclonal autoantibody; specific monoclonal; receptor specific ... See more keywords
Autoantibodies to the TSH Receptor—from discovery to understanding the mechanisms of action and to new therapeutics
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DOI: 10.1507/endocrj.ej25-0127
Abstract: Prior to 1956, Graves’ hyperthyroidism was thought to be due to high levels of TSH but in that year Adams & Purves demonstrated the presence of a thyroid stimulator in Graves’ sera with a prolonged… read more here.
Keywords: receptor; action; receptor discovery; graves hyperthyroidism ... See more keywords
Three Siblings Born to the Same Mother with Varying Degrees of Strong Positivity for Blocking Type TSH Receptor Antibodies.
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DOI: 10.2169/internalmedicine.5677-25
Abstract: A hypothyroid mother, due to thyroid stimulation-blocking antibody (TSBAb), gave birth three times. Although her TSBAb levels remained almost 100%, her TSH receptor antibody (TRAb) levels before delivery varied as follows: 315.0, 88.2 and 34.9… read more here.
Keywords: mother varying; receptor; siblings born; three siblings ... See more keywords
Characteristics of specific immunological indicators in patients with postoperative relapse of Graves’ disease
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Endocrinology"
DOI: 10.22141/2224-0721.14.1.2018.127095
Abstract: Background. Activity of autoimmune processes had a leading role in the development of relapse of hyperthyroidism. Level of thyroid-stimulating hormone (TSH) receptor antibodies is a basic factor that predetermines the relapse and can be used… read more here.
Keywords: patients postoperative; relapse; graves disease; postoperative relapse ... See more keywords
Commentary: Brief report - Monoclonal antibodies illustrate the difficulties in measuring blocking TSH receptor antibodies
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DOI: 10.3389/fendo.2022.1060280
Abstract: A Commentary on Brief report - Monoclonal antibodies illustrate the dif fi culties in measuring blocking TSH receptor antibodies the dif fi culties in measuring blocking TSH receptor read more here.
Keywords: commentary brief; brief report; blocking tsh; measuring blocking ... See more keywords
The Mysterious Universe of the TSH Receptor
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DOI: 10.3389/fendo.2022.944715
Abstract: The thyroid-stimulating hormone receptor (TSH-R) is predominantly expressed in the basolateral membrane of thyrocytes, where it stimulates almost every aspect of their metabolism. Several extrathyroidal locations of the receptor have been found including: the pituitary,… read more here.
Keywords: mysterious universe; tsh receptor; receptor; universe tsh ... See more keywords