Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00357-2
Abstract: A new paradigm of G-protein-coupled receptor (GPCR) signaling at intracellular sites has recently emerged, but the underlying mechanisms and functional consequences are insufficiently understood. Here, we show that upon internalization in thyroid cells, endogenous TSH… read more here.
Keywords: protein; tsh receptors; local protein; gene transcription ... See more keywords