MicroRNA-577 aggravates bone loss and bone remodeling by targeting thyroid stimulating hormone receptor in hyperthyroid-associated osteoporosis.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology"
DOI: 10.1002/tox.23419
Abstract: Traditionally, hyperthyroid-associated osteoporosis has been considered to be the result of increased thyroid hormone levels. The pathogenesis of hyperthyroid-associated osteoporosis remains unclear. Thyroid stimulating hormone receptor (TSHR) is closely associated with osteoporosis. Our study aimed… read more here.
Keywords: bone; tshr; associated osteoporosis; hyperthyroid associated ... See more keywords
Insulin-like growth factor-1 enhances the expression of functional TSH receptor in orbital fibroblasts from thyroid-associated ophthalmopathy.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.151902
Abstract: Thyroid-associated ophthalmopathy (TAO), an autoimmune disease, occurs in approximately 50 % of patients with Graves' hyperthyroidism. Thyroid-stimulating hormone receptor (TSHR) that is expressed in orbital fibroblasts is the autoimmune target in the development of TAO.… read more here.
Keywords: expression functional; tsh; orbital fibroblasts; igf ... See more keywords
Molecular cloning and variant analysis of the TSHR gene in goose (Anser cygnoides)
Sign Up to like & getrecommendations! Published in 2020 at "British Poultry Science"
DOI: 10.1080/00071668.2020.1751803
Abstract: ABSTRACT 1. The thyroid-stimulating hormone receptor (TSHR) is a glycoprotein hormone receptor which has a pivotal role in metabolic regulation and photoperiod control during reproduction in birds and mammals. However, the molecular characterisation of TSHR… read more here.
Keywords: tshr lacking; tshr gene; goose tshr; analysis ... See more keywords
TSH-TSHR axis promotes tumor immune evasion
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004049
Abstract: Background Hormones are identified as key biological variables in tumor immunity. However, previous researches mainly focused on the immune effect of steroid hormones, while the roles that thyroid-stimulating hormone (TSH) played in the antitumor response… read more here.
Keywords: immune evasion; tshr; tumor immune; tumor ... See more keywords
A Novel Long-Term Graves’ Disease Animal Model Confirmed by Functional Thyrotropin Receptor Antibodies
Sign Up to like & getrecommendations! Published in 2020 at "European Thyroid Journal"
DOI: 10.1159/000508790
Abstract: Introduction: A novel long-term murine model for Graves’ disease (GD) using repeated, long-term immunizations with recombinant adenovirus expressing the extracellular A-subunit of the human thyrotropin receptor (Ad-TSHR) was applied to evaluate the functional anti-TSHR-antibody (TSHR-Ab)… read more here.
Keywords: tbab tsab; novel long; long term; mice ... See more keywords
Modeling TSH Receptor Dimerization at the Transmembrane Domain.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac168
Abstract: Biophysical studies have established that the TSH receptor (TSHR) undergoes post translational modifications including dimerization. Following our earlier simulation of a TSH receptor - transmembrane domain (TMD) monomer (called TSHR-TMD-TRIO) we have now proceeded with… read more here.
Keywords: transmembrane domain; tshr; dimerization; tsh receptor ... See more keywords
Downregulated expression of TSHR is associated with distant metastasis in thyroid cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oncology letters"
DOI: 10.3892/ol.2017.7122
Abstract: In differentiated thyroid cancer (DTC), the association between thyroid-stimulating hormone receptor (TSHR) and metastasis, and the underlying molecular mechanisms remain unclear. The role of TSHR in the epithelial-mesenchymal transition (EMT) has not yet been reported,… read more here.
Keywords: distant metastasis; thyroid cancer; metastasis; expression ... See more keywords