MicroRNA-577 aggravates bone loss and bone remodeling by targeting thyroid stimulating hormone receptor in hyperthyroid-associated osteoporosis.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology"
DOI: 10.1002/tox.23419
Abstract: Traditionally, hyperthyroid-associated osteoporosis has been considered to be the result of increased thyroid hormone levels. The pathogenesis of hyperthyroid-associated osteoporosis remains unclear. Thyroid stimulating hormone receptor (TSHR) is closely associated with osteoporosis. Our study aimed… read more here.
Keywords: bone; tshr; associated osteoporosis; hyperthyroid associated ... See more keywords
Insulin-like growth factor-1 enhances the expression of functional TSH receptor in orbital fibroblasts from thyroid-associated ophthalmopathy.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.151902
Abstract: Thyroid-associated ophthalmopathy (TAO), an autoimmune disease, occurs in approximately 50 % of patients with Graves' hyperthyroidism. Thyroid-stimulating hormone receptor (TSHR) that is expressed in orbital fibroblasts is the autoimmune target in the development of TAO.… read more here.
Keywords: expression functional; tsh; orbital fibroblasts; igf ... See more keywords
Molecular cloning and variant analysis of the TSHR gene in goose (Anser cygnoides)
Sign Up to like & getrecommendations! Published in 2020 at "British Poultry Science"
DOI: 10.1080/00071668.2020.1751803
Abstract: ABSTRACT 1. The thyroid-stimulating hormone receptor (TSHR) is a glycoprotein hormone receptor which has a pivotal role in metabolic regulation and photoperiod control during reproduction in birds and mammals. However, the molecular characterisation of TSHR… read more here.
Keywords: tshr lacking; tshr gene; goose tshr; analysis ... See more keywords
Can inactivation mutation in the thyroid stimulating hormone receptor gene and hyperthyroidism coexist?: A case report
Sign Up to like & getrecommendations! Published in 2024 at "Medicine"
DOI: 10.1097/md.0000000000036950
Abstract: Introduction: We found the G132R heterozygous mutation of thyroid stimulating hormone receptor (TSHR) gene in a patient with recurrent hypokalemia. Because the patient had a medical history of hyperthyroidism, the mutation was suspected to be… read more here.
Keywords: hyperthyroidism; mutation thyroid; history; tshr ... See more keywords
TSH-TSHR axis promotes tumor immune evasion
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004049
Abstract: Background Hormones are identified as key biological variables in tumor immunity. However, previous researches mainly focused on the immune effect of steroid hormones, while the roles that thyroid-stimulating hormone (TSH) played in the antitumor response… read more here.
Keywords: immune evasion; tshr; tumor immune; tumor ... See more keywords
Abstract 54: Engineering chimeric antigen receptor (CAR) T cells using autoantigen binding domains for treatment of B cell malignancies with increased specificity
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-54
Abstract: Introduction: Chronic inflammation often leads to cancer, and many autoimmune diseases lead to a significantly increased risk of developing cancer. Though many autoimmune diseases, like Graves’ Disease (GD), don’t have treatments that address this risk.… read more here.
Keywords: tshr; tshr caar; anti tshr; cell ... See more keywords
A Novel Long-Term Graves’ Disease Animal Model Confirmed by Functional Thyrotropin Receptor Antibodies
Sign Up to like & getrecommendations! Published in 2020 at "European Thyroid Journal"
DOI: 10.1159/000508790
Abstract: Introduction: A novel long-term murine model for Graves’ disease (GD) using repeated, long-term immunizations with recombinant adenovirus expressing the extracellular A-subunit of the human thyrotropin receptor (Ad-TSHR) was applied to evaluate the functional anti-TSHR-antibody (TSHR-Ab)… read more here.
Keywords: tbab tsab; novel long; long term; mice ... See more keywords
Modeling TSH Receptor Dimerization at the Transmembrane Domain.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac168
Abstract: Biophysical studies have established that the TSH receptor (TSHR) undergoes post translational modifications including dimerization. Following our earlier simulation of a TSH receptor - transmembrane domain (TMD) monomer (called TSHR-TMD-TRIO) we have now proceeded with… read more here.
Keywords: transmembrane domain; tshr; dimerization; tsh receptor ... See more keywords
The TSH Receptor Antibody Reactome Contributes to Retro-Orbital Inflammation.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae182
Abstract: The thyroid eye disease (TED) of Graves disease is associated with high titers of stimulating TSH receptor antibodies, retro-orbital inflammation, fibroblast release of cytokines and chemokines, and adipogenesis, which in turn leads to proptosis, muscle… read more here.
Keywords: receptor; tshr; tsh receptor; orbital inflammation ... See more keywords
TSHR in thyroid cancer: bridging biological insights to targeted strategies
Sign Up to like & getrecommendations! Published in 2025 at "European Thyroid Journal"
DOI: 10.1530/etj-24-0369
Abstract: Traditionally, thyroid-stimulating hormone receptor (TSHR) has been utilized primarily to increase the efficacy of radioactive iodine therapy by promoting iodine uptake. However, the rise of personalized medicine has prompted reassessment of the potential of TSHR… read more here.
Keywords: bridging biological; tshr; thyroid cancer; cancer bridging ... See more keywords
The thyrotropin receptor structure and interactions with autoantibodies
Sign Up to like & getrecommendations! Published in 2025 at "European Thyroid Journal"
DOI: 10.1530/etj-25-0261
Abstract: Cryo-EM studies indicate that full-length human TSH receptor (TSHR) is a monomer consisting of a leucine-rich repeat (LRR) domain (LRD), hinge region (HR) and transmembrane domain (TMD). Receptor autoantibodies (TRAb) bind to the extracellular domain… read more here.
Keywords: receptor; tshr; monoclonal autoantibody; state ... See more keywords