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   Articles with "tsp1" as a keyword



Inhibition of thrombospondin-1 reduces glutathione activity and worsens acute liver injury during acetaminophen hepatotoxicity in mice.

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recommendations! Published in 2020 at "Toxicology and applied pharmacology"

DOI: 10.1016/j.taap.2020.115323

Abstract: Acetaminophen (N-Acetyl-p-Aminophenol or APAP)-induced hepatotoxicity is the most common cause of acute liver failure in the United States and Western Europe. Previous studies have shown that TGFβ1 is elevated during APAP-induced hepatotoxicity and promotes liver… read more here.

Keywords: tsp1; hepatotoxicity; mice; apap ... See more keywords

TSP1 ameliorates age-related macular degeneration by regulating the STAT3-iNOS signaling pathway.

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recommendations! Published in 2019 at "Experimental cell research"

DOI: 10.1016/j.yexcr.2019.111811

Abstract: Age-related macular degeneration is a progressive ocular disease that is the leading cause of vision loss among elderly. AMD usually is divided into two types: wet and dry AMD, which is linked with inflammation. Choroidal… read more here.

Keywords: tsp1 ameliorates; macular degeneration; age related; related macular ... See more keywords

Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-06177-2

Abstract: The incidence of aggressive neuroendocrine prostate cancers (NEPC) related to androgen-deprivation therapy (ADT) is rising. NEPC is still poorly understood, such as its neuroendocrine differentiation (NED) and angiogenic phenotypes. Here we reveal that NED and… read more here.

Keywords: prostate; angiogenesis; tsp1; androgen deprivation ... See more keywords

Critical role of thrombospondin-1 in promoting intestinal mucosal wound repair

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recommendations! Published in 2024 at "JCI Insight"

DOI: 10.1172/jci.insight.180608

Abstract: Thrombospondin-1 (TSP1) is a matricellular protein associated with the regulation of cell migration through direct binding interactions with integrin proteins and by associating with other receptors known to regulate integrin function, including CD47 and CD36.… read more here.

Keywords: intestinal mucosal; tsp1; wound repair; mucosal wound ... See more keywords