Inhibition of thrombospondin-1 reduces glutathione activity and worsens acute liver injury during acetaminophen hepatotoxicity in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2020.115323
Abstract: Acetaminophen (N-Acetyl-p-Aminophenol or APAP)-induced hepatotoxicity is the most common cause of acute liver failure in the United States and Western Europe. Previous studies have shown that TGFβ1 is elevated during APAP-induced hepatotoxicity and promotes liver… read more here.
Keywords: tsp1; hepatotoxicity; mice; apap ... See more keywords
TSP1 ameliorates age-related macular degeneration by regulating the STAT3-iNOS signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111811
Abstract: Age-related macular degeneration is a progressive ocular disease that is the leading cause of vision loss among elderly. AMD usually is divided into two types: wet and dry AMD, which is linked with inflammation. Choroidal… read more here.
Keywords: tsp1 ameliorates; macular degeneration; age related; related macular ... See more keywords
Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06177-2
Abstract: The incidence of aggressive neuroendocrine prostate cancers (NEPC) related to androgen-deprivation therapy (ADT) is rising. NEPC is still poorly understood, such as its neuroendocrine differentiation (NED) and angiogenic phenotypes. Here we reveal that NED and… read more here.
Keywords: prostate; angiogenesis; tsp1; androgen deprivation ... See more keywords