TSPAN8 alleviates high glucose‐induced apoptosis and autophagy via targeting mTORC2
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11870
Abstract: TSPAN8 mediates signal transduction from extracellular cues and regulates cell development, activation, growth, and motility. However, whether TSPAN8 is involved in the progression of diabetic nephropathy (DN) remains unclear. This study aimed to explore the… read more here.
Keywords: tspan8; apoptosis; apoptosis cells; high glucose ... See more keywords
TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10739-3
Abstract: Cancer stem cells (CSCs) represent a major source of treatment resistance and tumor progression. However, regulation of CSCs stemness is not entirely understood. Here, we report that TSPAN8 expression is upregulated in breast CSCs, promotes… read more here.
Keywords: stemness; sonic hedgehog; tspan8; expression ... See more keywords
Quantitative proteomics analysis of the role of tetraspanin-8 in the drug resistance of gastric cancer.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of oncology"
DOI: 10.3892/ijo.2017.4231
Abstract: Gastric cancer, due to its high incidence rate, is the second leading cause of cancer-related mortality worldwide. Chemotherapy is an important component of the multimodal treatment for gastric cancer; however, a significant impediment to successful… read more here.
Keywords: gastric cancer; sgc7901; tspan8; resistance ... See more keywords