Recombinant Overexpression of Mammalian TSPO Isoforms 1 and 2.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7151-0_1
Abstract: TSPO is a 18 kDa membrane protein that exists in mammalian as two isoforms 1 and 2. They are involved in different functions and are located in different membranes. TSPO1 is mainly located in outer… read more here.
Keywords: tspo; overexpression; tspo isoforms; mammalian tspo ... See more keywords
TSPO PET with [18F]GE-180 sensitively detects focal neuroinflammation in patients with relapsing–remitting multiple sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-018-3974-7
Abstract: PurposeExpression of the translocator protein (TSPO) is upregulated in activated macrophages/microglia and is considered to be a marker of neuroinflammation. We investigated the novel TSPO ligand [18F]GE-180 in patients with relapsing–remitting multiple sclerosis (RRMS) to… read more here.
Keywords: tspo; pet; relapsing remitting; 18f 180 ... See more keywords
Supervised clustering for TSPO PET imaging
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-021-05309-z
Abstract: This technical note seeks to act as a practical guide for implementing a supervised clustering algorithm (SVCA) reference region approach and to explain the main strengths and limitations of the technique in the context of… read more here.
Keywords: tspo; medicine; tspo pet; reference ... See more keywords
Increased Expression of Translocator Protein (TSPO) Marks Pro-inflammatory Microglia but Does Not Predict Neurodegeneration
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-017-1099-1
Abstract: PurposeActivation of the innate immune system plays a significant role in pathologies of the central nervous system (CNS). In order to follow disease progression and evaluate effectiveness of potential treatments involved in neuroinflammation, it is… read more here.
Keywords: tspo; protein tspo; translocator protein; expression ... See more keywords
New and Old TSPO PET Radioligands for Imaging Brain Microglial Activation in Neurodegenerative Disease
Sign Up to like & getrecommendations! Published in 2019 at "Current Neurology and Neuroscience Reports"
DOI: 10.1007/s11910-019-0934-y
Abstract: Purpose of ReviewWe will discuss the developments in TSPO PET imaging and the contribution this technique has had to understanding neuroinflammation in vivo, as well as the limitations inherent to the currently available radioligands and… read more here.
Keywords: tspo; new old; tspo pet; old tspo ... See more keywords
Evidence of fatigue, disordered sleep and peripheral inflammation, but not increased brain TSPO expression, in seasonal allergy: A [11C]PBR28 PET study
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.10.013
Abstract: Allergy is associated with non-specific symptoms such as fatigue, sleep problems and impaired cognition. One explanation could be that the allergic inflammatory state includes activation of immune cells in the brain, but this hypothesis has… read more here.
Keywords: tspo; fatigue; peripheral inflammation; allergy ... See more keywords
Versatile Dimerisation Process of Translocator Protein (TSPO) Revealed by an Extensive Sampling Based on a Coarse-Grained Dynamics Study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c00246
Abstract: Translocator protein (TSPO), a mitochondrial membrane protein, has been extensively studied and its role is still debated and continues to be enigmatic. From a structural perspective, despite availability of atomic structures from different species, the… read more here.
Keywords: tspo; protein; protein tspo; translocator protein ... See more keywords
Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure
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DOI: 10.1038/ncomms14893
Abstract: Cholesterol is an important regulator of membrane protein function. However, the exact mechanisms involved in this process are still not fully understood. Here we study how the tertiary and quaternary structure of the mitochondrial translocator… read more here.
Keywords: protein; tspo; mitochondrial translocator; cholesterol ... See more keywords
LncRNA MIAT impairs cardiac contractile function by acting on mitochondrial translocator protein TSPO in a mouse model of myocardial infarction
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00538-y
Abstract: Dear Editor, Long non-coding RNA MIAT (lncR-MIAT) has recently been identified as a risk factor for myocardial infarction (MI). However, how lncR-MIAT controls MI remained yet to be determined. To shed light on this issue,… read more here.
Keywords: tspo; lncr miat; supplementary fig; miat ... See more keywords
Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance
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DOI: 10.1080/15548627.2019.1659616
Abstract: ABSTRACT Hypothalamic glial cells named tanycytes, which line the 3rd ventricle (3V), are components of the hypothalamic network that regulates a diverse array of metabolic functions for energy homeostasis. Herein, we report that TSPO (translocator… read more here.
Keywords: tspo; tanycytic tspo; energy balance; protein ... See more keywords
Inhibition of translocator protein 18 kDa suppressed the progression of glioma via the ELAV-like RNA-binding protein 1/MAPK-activated protein kinase 3 axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2048992
Abstract: ABSTRACT Glioma is the most common primary malignant brain tumors in adults. Despite considerable advances in treatment, the clinical outcome remains dismal. Translocator protein 18 kDa (TSPO), an evolutionarily conserved transmembrane protein, has always been… read more here.
Keywords: hur; inhibition; translocator protein; tspo ... See more keywords