Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-022-02793-8
Abstract: Cerebral glucose hypometabolism is a typical hallmark of Alzheimer's disease (AD), usually associated with ongoing neurodegeneration and neuronal dysfunction. However, underlying pathological processes are not fully understood and reproducibility in animal models is not well… read more here.
Keywords: study; tspo expression; tau deposition; hypometabolism ... See more keywords
PET imaging of TSPO expression in immune cells can assess organ-level pathophysiology in high-consequence viral infections
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2110846119
Abstract: Significance Ebola virus (EBOV) infection is a severe, often fatal disease with poorly understood pathophysiology. Here, we performed [18F]-DPA-714 Positron Emission Tomography (PET) in a macaque model of EBOV infection to longitudinally track and quantify… read more here.
Keywords: organ level; pathophysiology; imaging tspo; tspo expression ... See more keywords
Increased [18F]DPA-714 Uptake in the Skeletal Muscle of SOD1G93A Mice: A New Potential of Translocator Protein 18 kDa Imaging in Amyotrophic Lateral Sclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Biomolecules"
DOI: 10.3390/biom15060799
Abstract: Purpose: The skeletal muscle has been proposed to contribute to the progressive loss of motor neurons typical of amyotrophic lateral sclerosis (ALS). However, this mechanism has not yet been clarified due to the lack of… read more here.
Keywords: skeletal muscle; muscle; dpa 714; tspo expression ... See more keywords