Imaging of the glioma microenvironment by TSPO PET
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-021-05276-5
Abstract: Gliomas are highly dynamic and heterogeneous tumours of the central nervous system (CNS). They constitute the most common neoplasm of the CNS and the second most common cause of death from intracranial disease after stroke.… read more here.
Keywords: pet; tspo pet; pet imaging; imaging glioma ... See more keywords
Supervised clustering for TSPO PET imaging
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-021-05309-z
Abstract: This technical note seeks to act as a practical guide for implementing a supervised clustering algorithm (SVCA) reference region approach and to explain the main strengths and limitations of the technique in the context of… read more here.
Keywords: tspo; medicine; tspo pet; reference ... See more keywords
New and Old TSPO PET Radioligands for Imaging Brain Microglial Activation in Neurodegenerative Disease
Sign Up to like & getrecommendations! Published in 2019 at "Current Neurology and Neuroscience Reports"
DOI: 10.1007/s11910-019-0934-y
Abstract: Purpose of ReviewWe will discuss the developments in TSPO PET imaging and the contribution this technique has had to understanding neuroinflammation in vivo, as well as the limitations inherent to the currently available radioligands and… read more here.
Keywords: tspo; new old; tspo pet; old tspo ... See more keywords
TSPO PET With 18F-GE-180 to Differentiate Variants of Multiple Sclerosis: Relapsing-Remitting Multiple Sclerosis, Tumefactive Demyelination, and Baló's Concentric Sclerosis.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Nuclear Medicine"
DOI: 10.1097/rlu.0000000000003220
Abstract: PET targeting the translocator protein (TSPO) expression is an interesting approach to detect neuroinflammation, as TSPO is upregulated in activated macrophages and microglia. Considering the variable pathophysiology of multiple sclerosis (MS) variants, we compare TSPO… read more here.
Keywords: tspo pet; concentric sclerosis; bal concentric; sclerosis ... See more keywords
Essential Principles and Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220329204054
Abstract: The translocator protein 18kDa (TSPO) is expressed in the outer mitochondrial membrane and is implicated in several functions, including cholesterol transport and stereoidogenesis. Under normal physiological conditions, TSPO is present in very low concentrations in… read more here.
Keywords: tspo pet; pet; tspo; development tspo ... See more keywords