Metabolic characterization of serum from mice challenged with Orientia tsutsugamushi–infected mites
Sign Up to like & getrecommendations! Published in 2018 at "New Microbes and New Infections"
DOI: 10.1016/j.nmni.2018.01.005
Abstract: Scrub typhus is an acute zoonosis caused by the obligate intracellular Gram-negative bacterium Orientia tsutsugamushi. To better understand the host response elicited by natural infection by chigger feeding, ICR mice were infected by Leptotrombidium chiangraiensis… read more here.
Keywords: orientia tsutsugamushi; mice infected; tsutsugamushi; serum ... See more keywords
Orientia tsutsugamushi Is Highly Susceptible to the RNA Polymerase Switch Region Inhibitor Corallopyronin A In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01732-17
Abstract: ABSTRACT Scrub typhus is a potentially lethal infection caused by the obligate intracellular bacterium Orientia tsutsugamushi. Reports on the emergence of doxycycline-resistant strains highlight the urgent need to develop novel antiinfectives against scrub typhus. Corallopyronin… read more here.
Keywords: orientia tsutsugamushi; vivo; tsutsugamushi; rna polymerase ... See more keywords
The Isolation of Orientia tsutsugamushi and Rickettsia typhi from Human Blood through Mammalian Cell Culture: a Descriptive Series of 3,227 Samples and Outcomes in the Lao People’s Democratic Republic
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.01553-20
Abstract: In the Lao People’s Democratic Republic (Laos), rickettsial infections, including scrub and murine typhus, account for a significant burden of fevers. The Mahosot Hospital Microbiology Laboratory in Vientiane, Laos, routinely performs rickettsial isolation from hospitalized… read more here.
Keywords: microbiology; cell culture; isolation; tsutsugamushi ... See more keywords
An Alternative Splicing Variant of the Mixed-Lineage Leukemia 5 Protein Is a Cellular Adhesion Receptor for ScaA of Orientia tsutsugamushi
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.01543-22
Abstract: O. tsutsugamushi is a mite-borne pathogen that causes scrub typhus. As an obligately intracellular pathogen, its adhesion to and invasion of host cells are critical steps for bacterial growth. ABSTRACT Scrub typhus is a mite-borne… read more here.
Keywords: adhesion; tsutsugamushi; vmll5; scaa ... See more keywords
Heterogeneity of Orientia tsutsugamushi genotypes in field-collected trombiculid mites from wild-caught small mammals in Thailand
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0006632
Abstract: Trombiculid mites are the vectors of scrub typhus, with infected larval mites (chiggers) transmitting the causative agent, Orientia tsutsugamushi, during feeding. Co-existence of multiple O. tsutsugamushi strains within infected mites has previously been reported in… read more here.
Keywords: orientia tsutsugamushi; tsutsugamushi; trombiculid mites; tsutsugamushi genotypes ... See more keywords
Genomic bacterial load associated with bacterial genotypes and clinical characteristics in patients with scrub typhus in Hainan Island, Southern China
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0011243
Abstract: Scrub typhus, caused by mite-borne Orientia tsutsugamushi (O. tsutsugamushi), is a major febrile disease in the Asia-Pacific region. The DNA load of O. tsutsugamushi in the blood was previously found to be significantly higher in… read more here.
Keywords: dna load; tsutsugamushi; scrub typhus; patients scrub ... See more keywords
Indoor and Outdoor Rodent Hosts of Orientia tsutsugamushi, Shandong Province, China
Sign Up to like & getrecommendations! Published in 2021 at "Emerging Infectious Diseases"
DOI: 10.3201/eid2710.210393
Abstract: During December 2012–July 2016, we tested small indoor and outdoor mammals in Qingdao, China, for Orientia tsutsugamushi infection. We found that outdoor Apodemus agrarius mice, Cricetulus barabensis hamsters, and Niviventer confucianus rats, as well as… read more here.
Keywords: outdoor rodent; orientia tsutsugamushi; tsutsugamushi; rodent hosts ... See more keywords
Evidence of natural infection of Orientia tsutsugamushi in vectors and animal hosts - Risk of scrub typhus transmission to humans in Puducherry, South India.
Sign Up to like & getrecommendations! Published in 2020 at "Indian journal of public health"
DOI: 10.4103/ijph.ijph_130_19
Abstract: Background Scrub typhus infection is endemic in India and reported to be the major cause for acute encephalitis syndrome (AES) in humans. Periodic occurrence of scrub typhus cases and presence of pathogen in rodents were… read more here.
Keywords: orientia tsutsugamushi; tsutsugamushi; risk scrub; scrub typhus ... See more keywords
Intranasal Vaccination with Outer-Membrane Protein of Orientia tsutsugamushi induces Protective Immunity Against Scrub Typhus
Sign Up to like & getrecommendations! Published in 2021 at "Immune Network"
DOI: 10.4110/in.2021.21.e14
Abstract: Scrub typhus develops after the individual is bitten by a trombiculid mite infected with Orientia tsutsugamushi. Since it has been reported that pneumonia is frequently observed in patients with scrub typhus, we investigated whether intranasal… read more here.
Keywords: vaccination; protective immunity; scrub typhus; tsutsugamushi ... See more keywords
Seasonality and Geographical Distribution of Tsutsugamushi Diseases in Japan: Analysis of the Trends since 1955 till 2014.
Sign Up to like & getrecommendations! Published in 2018 at "Japanese journal of infectious diseases"
DOI: 10.7883/yoken.jjid.2017.073
Abstract: Data concerning the seasonality and geographical location of tsutsugamushi disease (TD) in Japan from 1955 to 2014 were compiled. After disappearance of "classical" TD in the mid-1960s, there was a long near-vacuum. Then, in 1975,… read more here.
Keywords: tsutsugamushi; seasonality; october december; japan ... See more keywords