Metabolic characterization of serum from mice challenged with Orientia tsutsugamushi–infected mites
Sign Up to like & getrecommendations! Published in 2018 at "New Microbes and New Infections"
DOI: 10.1016/j.nmni.2018.01.005
Abstract: Scrub typhus is an acute zoonosis caused by the obligate intracellular Gram-negative bacterium Orientia tsutsugamushi. To better understand the host response elicited by natural infection by chigger feeding, ICR mice were infected by Leptotrombidium chiangraiensis… read more here.
Keywords: orientia tsutsugamushi; mice infected; tsutsugamushi; serum ... See more keywords
Orientia tsutsugamushi Is Highly Susceptible to the RNA Polymerase Switch Region Inhibitor Corallopyronin A In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01732-17
Abstract: ABSTRACT Scrub typhus is a potentially lethal infection caused by the obligate intracellular bacterium Orientia tsutsugamushi. Reports on the emergence of doxycycline-resistant strains highlight the urgent need to develop novel antiinfectives against scrub typhus. Corallopyronin… read more here.
Keywords: orientia tsutsugamushi; vivo; tsutsugamushi; rna polymerase ... See more keywords
Orientia tsutsugamushi infection reduces host gluconeogenic but not glycolytic substrates
Sign Up to like & getrecommendations! Published in 2024 at "Infection and Immunity"
DOI: 10.1128/iai.00284-24
Abstract: ABSTRACT Orientia tsutsugamushi a causal agent of scrub typhus, is an obligate intracellular bacterium that, akin to other rickettsiae, is dependent on host cell-derived nutrients for survival and thus pathogenesis. Based on limited experimental evidence… read more here.
Keywords: host gluconeogenic; host; tsutsugamushi; infection ... See more keywords
The Isolation of Orientia tsutsugamushi and Rickettsia typhi from Human Blood through Mammalian Cell Culture: a Descriptive Series of 3,227 Samples and Outcomes in the Lao People’s Democratic Republic
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.01553-20
Abstract: In the Lao People’s Democratic Republic (Laos), rickettsial infections, including scrub and murine typhus, account for a significant burden of fevers. The Mahosot Hospital Microbiology Laboratory in Vientiane, Laos, routinely performs rickettsial isolation from hospitalized… read more here.
Keywords: microbiology; cell culture; isolation; tsutsugamushi ... See more keywords
An Alternative Splicing Variant of the Mixed-Lineage Leukemia 5 Protein Is a Cellular Adhesion Receptor for ScaA of Orientia tsutsugamushi
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.01543-22
Abstract: O. tsutsugamushi is a mite-borne pathogen that causes scrub typhus. As an obligately intracellular pathogen, its adhesion to and invasion of host cells are critical steps for bacterial growth. ABSTRACT Scrub typhus is a mite-borne… read more here.
Keywords: adhesion; tsutsugamushi; vmll5; scaa ... See more keywords
A case of neonatal tsutsugamushi disease diagnosed with the aid of rickettsial macrogenomic detection
Sign Up to like & getrecommendations! Published in 2024 at "BMC Pediatrics"
DOI: 10.1186/s12887-024-04561-0
Abstract: Background Tsutsugamushi, also known as bush typhus, is a naturally occurring disease caused by Orientia tsutsugamushi. We reported a case of vertical mother-to-newborn transmission of Orientia tsutsugamushi infection in a newborn from Yunnan (China). Case… read more here.
Keywords: disease; case neonatal; tsutsugamushi; case ... See more keywords
Heterogeneity of Orientia tsutsugamushi genotypes in field-collected trombiculid mites from wild-caught small mammals in Thailand
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0006632
Abstract: Trombiculid mites are the vectors of scrub typhus, with infected larval mites (chiggers) transmitting the causative agent, Orientia tsutsugamushi, during feeding. Co-existence of multiple O. tsutsugamushi strains within infected mites has previously been reported in… read more here.
Keywords: orientia tsutsugamushi; tsutsugamushi; trombiculid mites; tsutsugamushi genotypes ... See more keywords
Genomic bacterial load associated with bacterial genotypes and clinical characteristics in patients with scrub typhus in Hainan Island, Southern China
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0011243
Abstract: Scrub typhus, caused by mite-borne Orientia tsutsugamushi (O. tsutsugamushi), is a major febrile disease in the Asia-Pacific region. The DNA load of O. tsutsugamushi in the blood was previously found to be significantly higher in… read more here.
Keywords: dna load; tsutsugamushi; scrub typhus; patients scrub ... See more keywords
Indoor and Outdoor Rodent Hosts of Orientia tsutsugamushi, Shandong Province, China
Sign Up to like & getrecommendations! Published in 2021 at "Emerging Infectious Diseases"
DOI: 10.3201/eid2710.210393
Abstract: During December 2012–July 2016, we tested small indoor and outdoor mammals in Qingdao, China, for Orientia tsutsugamushi infection. We found that outdoor Apodemus agrarius mice, Cricetulus barabensis hamsters, and Niviventer confucianus rats, as well as… read more here.
Keywords: outdoor rodent; orientia tsutsugamushi; tsutsugamushi; rodent hosts ... See more keywords
A longitudinal molecular surveillance of genetic heterogeneity of Orientia tsutsugamushi in humans, reservoir animals, and vectors in Puducherry, India
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2025.1634394
Abstract: Background Scrub typhus (ST), is a vector borne zoonotic disease, transmitted by the larva of the trombiculid mites. The enzootic cycle of the pathogen involves rodents/shrews as the animal reservoirs and humans are the accidental… read more here.
Keywords: puducherry india; tsutsugamushi; molecular surveillance; longitudinal molecular ... See more keywords
Concatenated ScaA and TSA56 Surface Antigen Sequences Reflect Genome-Scale Phylogeny of Orientia tsutsugamushi: An Analysis Including Two Genomes from Taiwan
Sign Up to like & getrecommendations! Published in 2024 at "Pathogens"
DOI: 10.3390/pathogens13040299
Abstract: Orientia tsutsugamushi is an obligate intracellular bacterium associated with trombiculid mites and is the causative agent of scrub typhus, a life-threatening febrile disease. Strain typing of O. tsutsugamushi is based on its immunodominant surface antigen,… read more here.
Keywords: surface antigen; core; antigen; analysis ... See more keywords