Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo.
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DOI: 10.1021/acs.jmedchem.1c00382
Abstract: Structural analysis of the known NIK inhibitor 3 bound to the kinase domain of TTBK1 led to the design and synthesis of a novel class of azaindazole TTBK1 inhibitors exemplified by 8 (cell IC50: 571… read more here.
Keywords: tau; discovery potent; ttbk1 inhibitors; kinase ... See more keywords