INNV-07. TUMOR TREATING FIELDS (TTFIELDS; 200 KHZ) POST-MARKETING SAFETY DATA FROM PATIENTS WITH GLIOBLASTOMA TREATED BETWEEN 2011–2022
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DOI: 10.1093/neuonc/noac209.547
Abstract: Tumor Treating Fields therapy (TTFields; 200 kHz) is a noninvasive, locoregional, antimitotic treatment approved for newly diagnosed glioblastoma (ndGBM), recurrent (r) GBM, malignant pleural mesothelioma, and is being investigated in additional solid tumors. Approval in… read more here.
Keywords: safety; 200 khz; ttfields therapy; data patients ... See more keywords
P27.27.A TUMOR TREATING FIELDS (TTFIELDS) THERAPY IN PATIENTS WITH GLIOBLASTOMA: LONG-TERM SURVIVAL RESULTS FROM TTFIELDS IN GERMANY IN ROUTINE CLINICAL CARE (TIGER) STUDY
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DOI: 10.1093/neuonc/noae144.489
Abstract: Tumor Treating Fields (TTFields) therapy has demonstrated significant improvements in overall survival (OS) and progression-free survival (PFS) when applied with adjuvant temozolomide (TMZ) compared to TMZ alone in newly diagnosed glioblastoma (ndGBM). TTFields therapy delivers… read more here.
Keywords: survival; routine clinical; tiger; study ... See more keywords
CTNI-25. TUMOR TREATING FIELDS (TTFIELDS) THERAPY WITH CHEMORADIATION, FOLLOWED BY MAINTENANCE TTFIELDS THERAPY/TEMOZOLOMIDE (TMZ), IN NEWLY DIAGNOSED GLIOBLASTOMA (NDGBM). RESULTS OF PHASE II CLINICAL STUDY
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DOI: 10.1093/neuonc/noae165.0392
Abstract: Tumor-Treating Fields (TTFields) are electric fields that exert physical forces to disrupt cancer cell function and tumor progression via a multimodal mechanism of action. Following the phase 3 pivotal EF-14 study, TTFields therapy concomitant with… read more here.
Keywords: maintenance; tmz; chemoradiation; tumor ... See more keywords
Enhancing Electric Field Distribution in the Pancreas for Improved TTFields Therapy: A Computational Modeling Investigation
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DOI: 10.1109/tbme.2024.3383818
Abstract: Background: Tumor treating fields (TTFields) therapy has shown effectiveness in glioblastoma treatment and holds potential for other cancers. However, its application in pancreatic cancer and the distribution of electric fields in pancreas remain unexplored. This… read more here.
Keywords: field; array configurations; distribution; field distributions ... See more keywords
Abstract CT061: TRIDENT phase 3 study (EF-32): First-line Tumor Treating Fields (TTFields; 200 kHz) therapy concomitant with chemo-radiation, followed by maintenance TTFields/temozolomide in newly diagnosed glioblastoma
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DOI: 10.1158/1538-7445.am2023-ct061
Abstract: Background: Tumor Treating Fields (TTFields) therapy is a loco-regional, noninvasive treatment approved for newly diagnosed (nd)/recurrent (r) glioblastoma (GBM) and mesothelioma. Approval for ndGBM was based on the pivotal phase 3 EF-14 study where TTFields… read more here.
Keywords: ttfields therapy; tmz; study; phase study ... See more keywords
Abstract 7100: Quantitative proteomics reveal the mechanism of TTFields therapy for glioblastoma
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DOI: 10.1158/1538-7445.am2024-7100
Abstract: Glioblastoma (GBM) is a highly malignant brain tumor, and conventional treatments such as surgical resection and chemotherapy have limited effectiveness, with a high rate of recurrence and poor prognosis for patients. In 2011, the FDA… read more here.
Keywords: quantitative proteomics; glioblastoma; proteomics reveal; ttfields treatment ... See more keywords
Results from METIS (EF-25), an international, multicenter phase III randomized study evaluating the efficacy and safety of tumor treating fields (TTFields) therapy in NSCLC patients with brain metastases.
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DOI: 10.1200/jco.2024.42.16_suppl.2008
Abstract: 2008 Background: For non-small cell lung cancer (NSCLC) with brain metastases (BM) stereotactic radiosurgery (SRS) is the current preferred therapy. Due to frequent intracranial failures, there is a high unmet need for salvage therapies. Whole… read more here.
Keywords: nsclc patients; brain; time; brain metastases ... See more keywords
Safety of Tumor Treating Fields (TTFields) therapy in pediatric patients with malignant brain tumors: Post-marketing surveillance data
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DOI: 10.3389/fonc.2022.958637
Abstract: There is an unmet need to develop effective and tolerable treatments for pediatric patients with malignant central nervous system tumors. This is especially essential for pediatric patients with aggressive brain tumors such as high-grade gliomas… read more here.
Keywords: therapy pediatric; safety; brain tumors; ttfields therapy ... See more keywords
Expert guidance on prophylaxis and treatment of dermatologic adverse events with Tumor Treating Fields (TTFields) therapy in the thoracic region
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DOI: 10.3389/fonc.2022.975473
Abstract: Tumor Treating Fields (TTFields) are electric fields, delivered via wearable arrays placed on or near the tumor site, that exert physical forces to disrupt cellular processes critical for cancer cell viability and tumor progression. As… read more here.
Keywords: thoracic region; ttfields therapy; treatment; tumor ... See more keywords
Case report: Safety of Tumor Treating Fields therapy with an implantable cardiac pacemaker in a patient with glioblastoma
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DOI: 10.3389/fonc.2024.1441146
Abstract: Tumor Treating Fields (TTFields) therapy is an anti-cancer treatment modality that is delivered noninvasively to the tumor site via skin-placed arrays. The therapy is US Food and Drug Administration (FDA) approved and Conformité Européenne (CE)… read more here.
Keywords: report; pacemaker; tumor treating; treating fields ... See more keywords
First Report of Tumor Treating Fields (TTFields) Therapy for Glioblastoma in Comorbidity with Multiple Sclerosis
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DOI: 10.3390/brainsci12040499
Abstract: Tumor Treating Fields (TTFields) therapy is FDA approved and has the CE mark for treatment of newly diagnosed and recurrent glioblastoma. To our knowledge, to date TTFields therapy remains unstudied in glioblastoma patients with multiple… read more here.
Keywords: treating fields; fields ttfields; ttfields therapy; multiple sclerosis ... See more keywords