Efficient route to pre-organized and linear polyaminopolycarboxylates: Cy-TTHA, Cy-DTPA and mono/di- reactive, tert-butyl protected TTHA/Cy-TTHA.
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron letters"
DOI: 10.1016/j.tetlet.2017.02.056
Abstract: Pre-organized polyaminopolycarboxylate chelators Cy-TTHA and Cy-DTPA were synthesized via modular five-step syntheses from commercially available starting materials in ~ 62% and 47% overall yields, respectively. Furthermore, strategies are reported for the efficient preparation of mono-… read more here.
Keywords: ttha dtpa; pre organized; ttha; tert butyl ... See more keywords
A Novel Paclitaxel Derivative for Triple-Negative Breast Cancer Chemotherapy
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DOI: 10.3390/molecules28093662
Abstract: Paclitaxel-triethylenetetramine hexaacetic acid conjugate (PTX-TTHA), a novel semi-synthetic taxane, is designed to improve the water solubility and cosolvent toxicity of paclitaxel in several aminopolycarboxylic acid groups. In this study, the in vitro and in vivo… read more here.
Keywords: ttha; breast cancer; ptx ttha; paclitaxel ... See more keywords