Ex vivo diffusion-weighted MRI tractography of the Göttingen minipig limbic system
Sign Up to like & getrecommendations! Published in 2020 at "Brain Structure and Function"
DOI: 10.1007/s00429-020-02058-x
Abstract: The limbic system encompasses a collection of brain areas primarily involved in higher cognitive and emotional processing. Altered function in the limbic circuitry may play a major role in various psychiatric disorders. This study aims… read more here.
Keywords: limbic system; ttingen minipig; system; minipig limbic ... See more keywords
Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2115425
Abstract: Abstract The use of the Göttingen minipig as an animal model for drug safety testing and prediction of human pharmacokinetics (PK) continues to gain momentum in pharmaceutical research and development. The aim of this study… read more here.
Keywords: clearance; vivo; minipig; ttingen minipig ... See more keywords
Histomorphometric evaluation of the Göttingen minipig eye.
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary ophthalmology"
DOI: 10.1111/vop.12665
Abstract: OBJECTIVE The Göttingen minipig is becoming a popular nonrodent animal model in ocular research; however, there is a paucity of literature regarding normative ocular reference data in this breed. We, therefore, investigated the characteristics of… read more here.
Keywords: ttingen minipig; layer males; males females; ttingen ... See more keywords
Refining experimental dental implant testing in the Göttingen Minipig using 3D computed tomography—A morphometric study of the mandibular canal
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0184889
Abstract: This study reports morphometric and age-related data of the mandibular canal and the alveolar ridge of the Göttingen Minipig to avoid complications during in vivo testing of endosseus dental implants and to compare these data… read more here.
Keywords: ttingen minipig; age; anatomy; study ... See more keywords
The Impact of Radiation Energy on Dose Homogeneity and Organ Dose in the Göttingen Minipig Total-Body Irradiation Model
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DOI: 10.1667/rade-20-00135.1
Abstract: Animal models of total-body irradiation (TBI) are used to elucidate normal tissue damage and evaluate the efficacy of medical countermeasures (MCM). The accuracy of these TBI models depends on the reproducibility of the radiation dose-response… read more here.
Keywords: total body; radiation; ttingen minipig; energy ... See more keywords
Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041112
Abstract: Antisense oligonucleotide (ASO) is a therapeutic modality that enables selective modulation of undruggable protein targets. However, dose- and sequence-dependent platelet count reductions have been reported in nonclinical studies and clinical trials. The adult Göttingen minipig… read more here.
Keywords: platelet; ttingen minipig; platelet activation;