In vitro Phase I- and Phase II-Drug Metabolism in The Liver of Juvenile and Adult Göttingen Minipigs
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2101-y
Abstract: PurposeIn view of pediatric drug development, juvenile animal studies are gaining importance. However, data on drug metabolizing capacities of juvenile animals are scarce, especially in non-rodent species. Therefore, we aimed to characterize the in vitro… read more here.
Keywords: adult; drug; day; drug metabolism ... See more keywords
Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2021.106956
Abstract: Göttingen Minipigs show several anatomical, physiological, and pathogenetical similarities to humans and serve an important role in translational studies for example as large animal models of disease. In recent years, the number of transgenic Göttingen… read more here.
Keywords: genisyst; disease; generation; disease modelling ... See more keywords
Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected
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DOI: 10.1038/s41598-021-81846-9
Abstract: Statins lower the risk of cardiovascular events but have been associated with mitochondrial functional changes in a tissue-dependent manner. We investigated tissue-specific modifications of mitochondrial function in liver, heart and skeletal muscle mediated by chronic… read more here.
Keywords: skeletal muscle; heart; muscle; group ... See more keywords
Hepatic blood flow in adult Göttingen minipigs and pre-pubertal Danish Landrace x Yorkshire pigs
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DOI: 10.1177/00236772211000370
Abstract: The liver receives dual blood supply from the hepatic artery and portal vein. The pig is often used as an animal model in positron emission tomography (PET) and pharmacokinetic studies because of the possibility for… read more here.
Keywords: blood flow; hepatic blood; blood; ttingen minipigs ... See more keywords
Cardiac Rhabdomyoma in Four Göttingen Minipigs.
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DOI: 10.1177/01926233221148393
Abstract: Göttingen minipigs are increasingly used as an alternative large animal model in nonclinical toxicology studies, and proliferative lesions in this species are rare. Here, we report four cases of cardiac rhabdomyoma in Göttingen minipigs, an… read more here.
Keywords: toxicology; ttingen minipigs; rhabdomyoma four; cardiac rhabdomyoma ... See more keywords
Evaluation of Loco-Regional Skin Toxicity Induced by an In Situ Forming Depot after a Single Subcutaneous Injection at Different Volumes and Flow Rates in Göttingen Minipigs
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DOI: 10.3390/ijms22179250
Abstract: The present study aims to investigate the loco-regional tolerability and injection parameters (i.e., flow rate and administration volume) of an in situ forming depot (ISFD) in Göttingen minipigs, to secure both the therapeutic procedure and… read more here.
Keywords: depot; loco regional; flow rates; injection ... See more keywords