Abstract 3017: Profiling patient response to TTK/PLK1 dual antagonist BAL0891 using 3D patient-derived organoid model in a microphysiological system
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DOI: 10.1158/1538-7445.am2025-3017
Abstract: Dysregulation of cell cycle checkpoints in cancer cells drives uncontrolled proliferation and tumor progression. Threonine Tyrosine Kinase (TTK) and Polo-like Kinase 1 (PLK1) are key regulators of the spindle assembly checkpoint (SAC) during mitotic division.… read more here.
Keywords: cancer; ttk plk1; patient derived; derived organoid ... See more keywords