PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12192
Abstract: Tristetraprolin (TTP) is an AU‐rich element‐binding protein that regulates mRNA stability and plays important roles in cancer. The mechanisms by which TTP is regulated in breast cancer are poorly understood. Using multiple biochemical approaches, we… read more here.
Keywords: pim2; cancer tumorigenesis; ttp; breast cancer ... See more keywords
Fat embolism syndrome due to bone marrow necrosis in patients with hemoglobinopathies: A life‐threatening complication mimicking thrombotic thrombocytopenic purpura
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25363
Abstract: To the Editor: Bone marrow necrosis (BMN) and embolization of fat and necrotic marrow is a rare, life-threatening condition in patients with sickle cell disorders (SCD). Fat emboli cause multiorgan failure with anemia and thrombocytopenia,… read more here.
Keywords: marrow necrosis; life threatening; ttp; mimicking thrombotic ... See more keywords
Laboratory testing for ADAMTS13: Utility for TTP diagnosis/exclusion and beyond
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26241
Abstract: The metalloproteinase ADAMTS13 (a disintegrin with a thrombospondin type 1 motif, member 13), also known as VWF (von Willebrand factor) protease, may be assessed in a vast array of clinical conditions. Notably, a severe deficiency… read more here.
Keywords: adamts13 utility; exclusion; laboratory testing; ttp ... See more keywords
Uncovering oxysterol‐binding protein (OSBP) as a target of the anti‐enteroviral compound TTP‐8307
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.01.008
Abstract: ABSTRACT The genus Enterovirus (e.g. poliovirus, coxsackievirus, rhinovirus) of the Picornaviridae family of positive‐strand RNA viruses includes many important pathogens linked to a range of acute and chronic diseases for which no approved antiviral therapy… read more here.
Keywords: ttp 8307; pi4kiii bgr; target; ttp ... See more keywords
Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.11.016
Abstract: Summary The immunosuppressive protein PD‐L1 is upregulated in many cancers and contributes to evasion of the host immune system. The relative importance of the tumor microenvironment and cancer cell‐intrinsic signaling in the regulation of PD‐L1… read more here.
Keywords: ttp; expression; ras signaling; oncogenic ras ... See more keywords
Tristetraprolin prevents gastric metaplasia in mice by suppressing pathogenic inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular gastroenterology and hepatology"
DOI: 10.1016/j.jcmgh.2021.07.015
Abstract: BACKGROUND & AIMS Aberrant immune activation is associated with numerous inflammatory and autoimmune diseases and contributes to cancer development and progression. Within the stomach, inflammation drives a well-established sequence from gastritis to metaplasia, eventually resulting… read more here.
Keywords: gastric inflammation; metaplasia; inflammation; ttp ... See more keywords
A case of primary lung squamous cell carcinoma mimicking malignant mesothelioma producing granulocyte colony stimulating factor with chemotherapy (cisplatin and gemcitabine)-associated thrombotic thrombocytopenic purpura (TTP); An autopsy case report.
Sign Up to like & getrecommendations! Published in 2019 at "Lung cancer"
DOI: 10.1016/j.lungcan.2019.08.018
Abstract: OBJECTIVES Thrombotic thrombocytopenic purpura (TTP) is a rare form of thrombotic microangiopathy. In recent years, an extensive variety of drugs, including certain cytotoxic agents, have been reported to be associated with TTP. Additionally, several studies… read more here.
Keywords: chemotherapy; carcinoma; squamous cell; case ... See more keywords
Impaired insulin signaling upon loss of ovarian function is associated with a reduction of tristetraprolin and an increased stabilization of chemokine in adipose tissue
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.09.002
Abstract: Loss of ovarian function can activate inflammation and lead to insulin resistance (IR). IR is also a core feature of obesity and obesity-associated metabolic dysfunction. Tristetraprolin/zinc finger protein 36 (TTP) interferes with TNF-α production by… read more here.
Keywords: insulin; ovarian function; ttp; impaired insulin ... See more keywords
Regulation of the ARE-binding proteins, TTP (tristetraprolin) and HuR (human antigen R), in inflammatory response in astrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2018.04.014
Abstract: ABSTRACT Control of decay of mRNA containing the adenine‐uridine rich elements (AREs) is an important post‐transcriptional mechanism involved in the regulation of inflammatory gene expression. Two widely recognized proteins in this machinery are HuR (human… read more here.
Keywords: hur human; human antigen; hur; ttp ... See more keywords
Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101609
Abstract: Tristetraprolin (TTP), an mRNA binding and decaying protein, plays a significant role in controlling inflammation by decaying mRNAs encoding inflammatory cytokines such as TNFalpha. We aimed to test a hypothesis that TTP in bone marrow… read more here.
Keywords: ttp; inflammation; mice; bone marrow ... See more keywords
The RNA binding protein tristetraprolin down‐regulates autophagy in lung adenocarcinoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.03.028
Abstract: ABSTRACT Tristetraprolin (TTP) is the most well‐known member of RNA‐binding zinc‐finger protein that play a significant role in accelerating mRNA decay. Increasingly studies have reported that TTP was functioned as a tumor suppressor gene in… read more here.
Keywords: lung adenocarcinoma; cell; adenocarcinoma cells; ttp ... See more keywords