A phenomap of TTR amyloidosis to aid diagnostic screening
Sign Up to like & getrecommendations! Published in 2024 at "ESC Heart Failure"
DOI: 10.1002/ehf2.15143
Abstract: Cardiac amyloidosis due to transthyretin (ATTR) remains an underdiagnosed cause of cardiomyopathy. As awareness of the disease grows and referrals for ATTR increase, clinicians are likely to encounter more atypical forms of the condition in… read more here.
Keywords: disease; attr; phenomap; ttr ... See more keywords
Silencers versus stabilizers in amyloid cardiomyopathy. Are we asking the wrong questions?
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.3614
Abstract: Transthyretin (TTR) is a small tetrameric molecule with a half-life of 2–2.5days. 1 TTR cardiomyopathy is an increasingly recognized cause of progressive heart failure in the elderly and is associated with amyloid production derived from… read more here.
Keywords: amyloid cardiomyopathy; ttr; silencers versus; stabilizers amyloid ... See more keywords
Mispacking of the F87 sidechain drives aggregation‐promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer
Sign Up to like & getrecommendations! Published in 2024 at "Protein Science"
DOI: 10.1002/pro.5101
Abstract: Aberrant formation and deposition of human transthyretin (TTR) aggregates causes transthyretin amyloidosis. To initialize aggregation, transthyretin tetramers must first dissociate into monomers that partially unfold to promote entry into the aggregation pathway. The native TTR… read more here.
Keywords: ttr; tetramer; f87 sidechain; aggregation ... See more keywords
FRET studies of various conformational states adopted by transthyretin
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2533-x
Abstract: Transthyretin (TTR) is an extracellular protein able to deposit into well-defined protein aggregates called amyloid, in pathological conditions known as senile systemic amyloidosis, familial amyloid polyneuropathy, familial amyloid cardiomyopathy and leptomeningeal amyloidosis. At least three… read more here.
Keywords: state; fret efficiency; fret studies; conformational states ... See more keywords
Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03357-1
Abstract: Transthyretin amyloidosis (ATTR) is a progressive life-threatening disease characterized by the deposition of transthyretin (TTR) amyloid fibrils. Several pathogenic variants have been shown to destabilize TTR tetramers, leading to aggregation of misfolded TTR fibrils. However,… read more here.
Keywords: late onset; ttr; amyloidosis; underlie late ... See more keywords
Clinical improvement after change of therapy from tafamidis to patisiran in progressive TTR amyloidosis post-liver transplantation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurology"
DOI: 10.1007/s00415-022-10978-3
Abstract: Hereditary amyloidosis with autosomal-dominant mutations in the transthyretin-gene (TTR) represents a severe multisystem disorder. Treatment options are now available for TTR familial amyloid polyneuropathy (TTR-FAP): patisiran [1], inotersen [2], tafamidis [3] and orthotopic liver transplantation… read more here.
Keywords: therapy; tafamidis; ttr; amyloidosis ... See more keywords
International normalized ratio control and subsequent clinical outcomes in patients with atrial fibrillation using warfarin
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-019-01858-1
Abstract: We explored associations between INR measures and clinical outcomes in patients with AF using warfarin, and whether INR history predicted future INR measurements. We included patients in ARISTOTLE who were randomized to and received warfarin.… read more here.
Keywords: outcomes patients; clinical outcomes; control; ttr ... See more keywords
Patisiran: First Global Approval
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DOI: 10.1007/s40265-018-0983-6
Abstract: Patisiran (ONPATTRO™) is a double-stranded small interfering RNA encapsulated in a lipid nanoparticle for delivery to hepatocytes. By specifically binding to a genetically conserved sequence in the 3′ untranslated region of mutant and wild-type transthyretin… read more here.
Keywords: patisiran; ttr; global approval; patisiran first ... See more keywords
Eplontersen: First Approval
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DOI: 10.1007/s40265-024-02008-5
Abstract: Eplontersen (Wainua™) is a ligand-conjugated antisense oligonucleotide directed to TTR, which is being developed by Ionis Pharmaceuticals and AstraZeneca for the treatment of TTR-mediated amyloidosis (ATTR). Eplontersen, which is targeted to the liver by a… read more here.
Keywords: attr; ttr; first approval; eplontersen first ... See more keywords
Progressive Cardiomyopathy in TTR Amyloidosis after Liver Transplant
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cardiac Failure"
DOI: 10.1016/j.cardfail.2018.07.326
Abstract: Introduction Familial transthyretin (TTR) amyloidosis is a rare disorder characterized primarily by progressive neuropathy and cardiomyopathy. The source of amyloid protein is the liver, thus early liver transplantation can significantly slow disease progression. Unfortunately, for… read more here.
Keywords: ttr amyloidosis; ttr; liver transplant; amyloidosis ... See more keywords
Is transthyretin a good marker of nutritional status?
Sign Up to like & getrecommendations! Published in 2017 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2016.06.004
Abstract: The assay of plasma transthyretin (TTR), also known as prealbumin, is a key step in the assessment of nutritional status. However, it remains unclear whether it really is a useful nutrition marker, and when and… read more here.
Keywords: malnutrition; ttr; nutritional status; good marker ... See more keywords