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Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2533-x
Abstract: Transthyretin (TTR) is an extracellular protein able to deposit into well-defined protein aggregates called amyloid, in pathological conditions known as senile systemic amyloidosis, familial amyloid polyneuropathy, familial amyloid cardiomyopathy and leptomeningeal amyloidosis. At least three…
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Keywords:
state;
fret efficiency;
fret studies;
conformational states ... See more keywords
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Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03357-1
Abstract: Transthyretin amyloidosis (ATTR) is a progressive life-threatening disease characterized by the deposition of transthyretin (TTR) amyloid fibrils. Several pathogenic variants have been shown to destabilize TTR tetramers, leading to aggregation of misfolded TTR fibrils. However,…
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Keywords:
late onset;
ttr;
amyloidosis;
underlie late ... See more keywords
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Published in 2022 at "Journal of Neurology"
DOI: 10.1007/s00415-022-10978-3
Abstract: Hereditary amyloidosis with autosomal-dominant mutations in the transthyretin-gene (TTR) represents a severe multisystem disorder. Treatment options are now available for TTR familial amyloid polyneuropathy (TTR-FAP): patisiran [1], inotersen [2], tafamidis [3] and orthotopic liver transplantation…
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Keywords:
therapy;
tafamidis;
ttr;
amyloidosis ... See more keywords
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Published in 2019 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-019-01858-1
Abstract: We explored associations between INR measures and clinical outcomes in patients with AF using warfarin, and whether INR history predicted future INR measurements. We included patients in ARISTOTLE who were randomized to and received warfarin.…
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Keywords:
outcomes patients;
clinical outcomes;
control;
ttr ... See more keywords
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Published in 2018 at "Drugs"
DOI: 10.1007/s40265-018-0983-6
Abstract: Patisiran (ONPATTRO™) is a double-stranded small interfering RNA encapsulated in a lipid nanoparticle for delivery to hepatocytes. By specifically binding to a genetically conserved sequence in the 3′ untranslated region of mutant and wild-type transthyretin…
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Keywords:
patisiran;
ttr;
global approval;
patisiran first ... See more keywords
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Published in 2018 at "Journal of Cardiac Failure"
DOI: 10.1016/j.cardfail.2018.07.326
Abstract: Introduction Familial transthyretin (TTR) amyloidosis is a rare disorder characterized primarily by progressive neuropathy and cardiomyopathy. The source of amyloid protein is the liver, thus early liver transplantation can significantly slow disease progression. Unfortunately, for…
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Keywords:
ttr amyloidosis;
ttr;
liver transplant;
amyloidosis ... See more keywords
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Published in 2017 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2016.06.004
Abstract: The assay of plasma transthyretin (TTR), also known as prealbumin, is a key step in the assessment of nutritional status. However, it remains unclear whether it really is a useful nutrition marker, and when and…
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Keywords:
malnutrition;
ttr;
nutritional status;
good marker ... See more keywords
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Published in 2021 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.1950
Abstract: Purpose Time in Therapeutic range (TTR) is the percentage of time an anticoagulated patient has an INR between 2-3. While studies have demonstrated a link between low TTR, bleeding and thrombosis, the mean TTR in…
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Keywords:
time;
time therapeutic;
ttr;
vad ... See more keywords
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Published in 2017 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2017.08.017
Abstract: Familial amyloid polyneuropathy (FAP) is an autosomal dominant hereditary systemic amyloidosis caused by mutation of the transthyretin (TTR) gene, and usually shows sensory-dominant polyneuropathy and autonomic neuropathy at the initial stage. The pathogenesis of this…
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Keywords:
e61k mutation;
amyloid polyneuropathy;
ttr;
familial amyloid ... See more keywords
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Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00517
Abstract: β-Amyloid (Aβ) aggregation is causally linked to Alzheimer's disease. On the basis of in vitro and transgenic animal studies, transthyretin (TTR) is hypothesized to provide neuroprotection against Aβ toxicity by binding to Aβ and inhibiting…
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Keywords:
protein;
aggregation;
hrbp;
ttr ... See more keywords
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Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00823
Abstract: Transthyretin (TTR) is a causative protein of TTR amyloidosis (ATTR amyloidosis), a general term for diseases characterized by deposition of TTR amyloid fibrils in specific organs. ATTR amyloidosis can be ameliorated by stabilization of the…
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Keywords:
bithionol triclabendazole;
ttr;
drugs bithionol;
amyloidosis ... See more keywords