Development of a highly sensitive detection method for TTX based on a magnetic bead-aptamer competition system under triple cycle amplification.
Sign Up to like & getrecommendations! Published in 2020 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2020.04.050
Abstract: We have established an assay that relies on aptamer and isothermal amplification for the tetrodotoxin (TTX)detection. The method uses triple cycle amplification (strand displacement amplification combined with catalytic hairpin assembly) and fluorescent reporter as an… read more here.
Keywords: triple cycle; detection; method; ttx ... See more keywords
Tetrodotoxin levels of three pufferfish species (Lagocephalus sp.) caught in the North-Eastern Mediterranean sea.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.12.010
Abstract: Tetrodotoxin (TTX) levels in Lagocephalus sceleratus (Silverstripe blaasop), Lagocephalus spadiceus (Half-smooth golden pufferfish) and Lagocephalus suezensis (Suez puffer) caught in Mersin Bay in the Northeastern Mediterranean Sea were analysed using Q-TOF LC/MS. Pufferfish were caught… read more here.
Keywords: tetrodotoxin; eastern mediterranean; mediterranean sea; north eastern ... See more keywords
Tetrodotoxin in marine bivalves and edible gastropods: A mini-review.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.124404
Abstract: Tetrodotoxin (TTX) is a potent neurotoxin responsible for countless human intoxications and deaths around the world. The distribution of TTX and its analogues is diverse and the toxin has been detected in organisms from both… read more here.
Keywords: edible gastropods; gastropods mini; bivalves edible; ttx ... See more keywords
New tetrodotoxin analogs in Brazilian pufferfishes tissues and microbiome.
Sign Up to like & getrecommendations! Published in 2020 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.125211
Abstract: While tetrodotoxin (TTX) is commonly found in pufferfish tissues, it is unclear if bacterial symbionts isolated from pufferfish tissues can produce TTX. In this investigation, UPLC qTOF-MS/MS analysis of tissue extracts obtained from Sphoeroides spengleri… read more here.
Keywords: tetrodotoxin; brazilian pufferfishes; tetrodotoxin analogs; analogs brazilian ... See more keywords
Isolation and Biological Activity of 9-epiTetrodotoxin and Isolation of Tb-242B, Possible Biosynthetic Shunt Products of Tetrodotoxin from Pufferfish.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00588
Abstract: Tetrodotoxin (TTX, 1) is a potent voltage-gated sodium channel blocker detected in certain marine and terrestrial organisms. We report here a new TTX analogue, 9-epiTTX (2), and a TTX-related compound, Tb-242B (4), isolated from the… read more here.
Keywords: possible biosynthetic; biological activity; ttx; isolation ... See more keywords
Interlaboratory Evaluation of Multiple LC–MS/MS Methods and a Commercial ELISA Method for Determination of Tetrodotoxin in Oysters and Mussels
Sign Up to like & getrecommendations! Published in 2023 at "Journal of AOAC International"
DOI: 10.1093/jaoacint/qsad006
Abstract: Abstract Background Given the recent detection of tetrodotoxin (TTX) in bivalve molluscs but the absence of a full collaborative validation study for TTX determination in a large number of shellfish samples, interlaboratory assessment of method… read more here.
Keywords: methods commercial; tetrodotoxin; ttx; commercial elisa ... See more keywords
Levels and distribution of tetrodotoxin in the blue-lined octopus Hapalochlaena fasciata in Japan, with special reference to within-body allocation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molluscan Studies"
DOI: 10.1093/mollus/eyaa042
Abstract: The toxins present in poisonous and venomous animals have both offensive and defensive functions. The blue-lined octopus Hapalochlaena fasciata has tetrodotoxin (TTX) in various organs, including the salivary glands, muscles and skin, and TTX is… read more here.
Keywords: body; allocation; ttx; blue lined ... See more keywords
Beyond lidocaine: selective voltage-gated sodium channel blockade for vaginal pain.
Sign Up to like & getrecommendations! Published in 2020 at "Pain"
DOI: 10.1097/j.pain.0000000000002037
Abstract: Female reproductive tract pain encompasses a variety of common and debilitating conditions such as vulvodynia, vaginal hyperalgesia secondary to endometriosis, pudendal neuralgia, and many others. These conditions lack effective pharmacotherapies due to a poor understanding… read more here.
Keywords: nav channels; ttx; channel; vaginal pain ... See more keywords
A concise synthesis of tetrodotoxin
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abn0571
Abstract: Tetrodotoxin (TTX) is a neurotoxic natural product that is an indispensable probe in neuroscience, a biosynthetic and ecological enigma, and a celebrated target of synthetic chemistry. Here, we present a stereoselective synthesis of TTX that… read more here.
Keywords: dipolar cycloaddition; tetrodotoxin; synthesis; ttx ... See more keywords
Risks for public health related to the presence of tetrodotoxin (TTX) and TTX analogues in marine bivalves and gastropods
Sign Up to like & getrecommendations! Published in 2017 at "EFSA Journal"
DOI: 10.2903/j.efsa.2017.4752
Abstract: Abstract Tetrodotoxin (TTX) and its analogues are produced by marine bacteria and have been detected in marine bivalves and gastropods from European waters. The European Commission asked EFSA for a scientific opinion on the risks… read more here.
Keywords: marine bivalves; ttx analogues; bivalves gastropods; risks public ... See more keywords
Seasonal and Spatial Variations in Bacterial Communities From Tetrodotoxin-Bearing and Non-tetrodotoxin-Bearing Clams
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.01860
Abstract: Tetrodotoxin (TTX) is one of the most potent naturally occurring compounds and is responsible for many human intoxications worldwide. Paphies australis are endemic clams to New Zealand which contain varying concentrations of TTX. Research suggests… read more here.
Keywords: tetrodotoxin bearing; bacterial communities; ttx; hokianga harbor ... See more keywords