NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109516
Abstract: Although tumor-infiltrating lymphocytes (TILs) maintain their ability to proliferate, persist, and eradicate tumors, they are frequently dysfunctional in situ. By performing both whole-genome CRISPR and metabolic inhibitor screens, we identify that nicotinamide phosphoribosyltransferase (NAMPT) is… read more here.
Keywords: tumor killing; tub; nad supplement; function ... See more keywords
Intracellular pH-Regulating Nanoparticles to Improve Anticancer Drug Efficacy for Cancer Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00952
Abstract: Here, we describe an intracellular pH-regulating nanoparticle (IPRN), coencapsulated with chemosensitizers and anticancer agents for effective and safe cancer treatment. IPRN contains a tubulysin derivative (TUB), a hydrophobic anticancer drug, and pantoprazole (PTZ), a hydrophilic… read more here.
Keywords: iprn; tub; intracellular regulating; drug ... See more keywords
First Report of Bayberry Leaf Blight Caused by Pestalotiopsis kenyana in Zhejiang Province, China.
Sign Up to like & getrecommendations! Published in 2023 at "Plant disease"
DOI: 10.1094/pdis-03-23-0450-pdn
Abstract: Weizhi Xun and Changwang Wu contributed equally to this work In October 2020, bayberry (Myrica rubra (Lour.) S. et Zucc.) leaves that beginning to wither were collected in Wencheng County (N27°50', E120°03'). In the county,… read more here.
Keywords: tub; disease; identity; bayberry ... See more keywords
First Report of Fusarium falciforme Causing Leaf Blight in Acacia mangium in China.
Sign Up to like & getrecommendations! Published in 2022 at "Plant disease"
DOI: 10.1094/pdis-07-22-1583-pdn
Abstract: Acacia mangium Willd. is an important economic tree species with diverse uses and high ecological value, used in agriculture, restoration of degraded lands, for ornamental purposes, and commercial forestry (Leroy et al. 2009). This tree… read more here.
Keywords: tub; mangium; leaf blight; sequences matched ... See more keywords
Legionnaires' Disease Outbreak Associated With a Hot Tub Display at the North Carolina Mountain State Fair, September 2019.
Sign Up to like & getrecommendations! Published in 2023 at "Public health reports"
DOI: 10.1177/00333549231159159
Abstract: OBJECTIVES On September 23, 2019, the North Carolina Division of Public Health identified a legionellosis increase in western North Carolina; most patients had recently attended the North Carolina Mountain State Fair. We conducted a source… read more here.
Keywords: legionnaires disease; hot tub; tub; north carolina ... See more keywords
Acute exercise reduces feeding by activating IL-6/Tubby axis in the mouse hypothalamus
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.956116
Abstract: Background: Acute exercise contributes to decreased feeding through leptin and interleukin/Janus kinase 2/signal transducers and activators of transcription 3 (IL-6/JAK2/STAT3) signaling. Considering the pleiotropic use of substrates by JAK2 and that JAK2 can phosphorylate the… read more here.
Keywords: tub; acute exercise; jak2; exercise reduces ... See more keywords
Rectal Temperature Cooling Rates in the PolarLife Pod are Excellent and Consistent with Stationary Tubs.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of athletic training"
DOI: 10.4085/1062-6050-0732.21
Abstract: CONTEXT Several tools exist to reduce rectal temperature (TREC) quickly for patients experiencing exertional heatstroke (EHS). Stationary tubs (TUB) effectively treat EHS but are bulky and impractical in some situations. More portable cold-water immersion (CWI)… read more here.
Keywords: plp tub; tub; cooling rates; rectal temperature ... See more keywords