Two cooperative binding sites sensitize PI(4,5)P2 recognition by the tubby domain
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DOI: 10.1126/sciadv.abp9471
Abstract: Phosphoinositides (PIs) are lipid signaling molecules that operate by recruiting proteins to cellular membranes via PI recognition domains. The dominant PI of the plasma membrane is phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. One of only two PI(4,5)P2 recognition… read more here.
Keywords: recognition; tubby domain; two cooperative; membrane ... See more keywords
Distribution of ciliary adaptor proteins tubby and TULP3 in the organ of Corti
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1162937
Abstract: Tubby-like proteins are membrane-associated adaptors that mediate directional trafficking into primary cilia. In inner ear sensory epithelia, cilia—including the hair cell’s kinocilium—play important roles as organizers of polarity, tissue architecture and cellular function. However, auditory… read more here.
Keywords: localization; distribution ciliary; tubby tulp3; hair ... See more keywords
Acute exercise reduces feeding by activating IL-6/Tubby axis in the mouse hypothalamus
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DOI: 10.3389/fphys.2022.956116
Abstract: Background: Acute exercise contributes to decreased feeding through leptin and interleukin/Janus kinase 2/signal transducers and activators of transcription 3 (IL-6/JAK2/STAT3) signaling. Considering the pleiotropic use of substrates by JAK2 and that JAK2 can phosphorylate the… read more here.
Keywords: tub; acute exercise; jak2; exercise reduces ... See more keywords