Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-10-0473
Abstract: The primary cilium is a nexus for cell signaling and relies on specific protein trafficking for function. The tubby family protein TULP3 transports integral membrane proteins into cilia through interactions with the intraflagellar transport complex-A… read more here.
Keywords: amphipathic helix; domain arl13b; tubby domain; domain ... See more keywords
Two cooperative binding sites sensitize PI(4,5)P2 recognition by the tubby domain
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abp9471
Abstract: Phosphoinositides (PIs) are lipid signaling molecules that operate by recruiting proteins to cellular membranes via PI recognition domains. The dominant PI of the plasma membrane is phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. One of only two PI(4,5)P2 recognition… read more here.
Keywords: recognition; tubby domain; two cooperative; membrane ... See more keywords