G-protein-coupled receptor signaling and neural tube closure defects.
Sign Up to like & getrecommendations! Published in 2017 at "Birth defects research"
DOI: 10.1002/bdra.23567
Abstract: Disruption of the normal mechanisms that mediate neural tube closure can result in neural tube defects (NTDs) with devastating consequences in affected patients. With the advent of next-generation sequencing, we are increasingly detecting mutations in… read more here.
Keywords: tube; protein coupled; neural tube; tube closure ... See more keywords
Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate-induced neural tube closure defects.
Sign Up to like & getrecommendations! Published in 2017 at "Birth defects research"
DOI: 10.1002/bdra.23583
Abstract: BACKGROUND Valproic acid (VPA) is prescribed therapeutically for multiple conditions, including epilepsy. When taken during pregnancy, VPA is teratogenic, increasing the risk of several birth and developmental defects including neural tube defects (NTDs). The mechanism… read more here.
Keywords: vpa; embryos; neural tube; tube closure ... See more keywords
CRISPR/Cas9-mediated gene editing on Sox2ot promoter leads to its truncated expression and does not influence neural tube closure and embryonic development in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.08.029
Abstract: Sox2 overlapping transcript (Sox2ot) is a long non-coding RNA (lncRNA), which harbors one of the major regulators of pluripotency, the Sox2 gene, in its intronic region. Sox2ot is primarily expressed in the developing neuroepithelium. However,… read more here.
Keywords: sox2ot promoter; embryonic development; neural tube; tube closure ... See more keywords
hmmr mediates anterior neural tube closure and morphogenesis in the frog Xenopus.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.07.020
Abstract: Development of the central nervous system requires orchestration of morphogenetic processes which drive elevation and apposition of the neural folds and their fusion into a neural tube. The newly formed tube gives rise to the… read more here.
Keywords: anterior neural; tube; hmmr; neural tube ... See more keywords
A Nonredundant Role for the TRPM6 Channel in Neural Tube Closure
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15855-y
Abstract: In humans, germline mutations in Trpm6 cause autosomal dominant hypomagnesemia with secondary hypocalcemia disorder. Loss of Trpm6 in mice also perturbs cellular magnesium homeostasis but additionally results in early embryonic lethality and neural tube closure… read more here.
Keywords: neural tube; trpm6; tube closure; xtrpm6 ... See more keywords
Somitic mesoderm morphogenesis is necessary for neural tube closure during Xenopus development
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1091629
Abstract: Neural tube closure is a fundamental process during vertebrate embryogenesis, which leads to the formation of the central nervous system. Defective neural tube closure leads to neural tube defects which are some of the most… read more here.
Keywords: morphogenesis; somitic mesoderm; tube closure; tube ... See more keywords
Pax3/7 regulates neural tube closure and patterning in a non-vertebrate chordate
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.999511
Abstract: Pax3/7 factors play numerous roles in the development of the dorsal nervous system of vertebrates. From specifying neural crest at the neural plate borders, to regulating neural tube closure and patterning of the resulting neural… read more here.
Keywords: closure patterning; tube closure; pax3; tube ... See more keywords
Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.60234
Abstract: Neural tube closure defects are a major cause of infant mortality, with exencephaly accounting for nearly one-third of cases. However, the mechanisms of cranial neural tube closure are not well understood. Here, we show that… read more here.
Keywords: neural tube; tube closure; cranial neural; apical constriction ... See more keywords