Repositioning of Isatin hybrids as novel anti-tubercular agents overcoming pre-existing antibiotics resistance
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-021-02699-5
Abstract: The widespread deaths of tuberculosis from many decades demands an urgent need for the development of novel anti-tubercular scaffolds that are more potent and highly selective with lower cytotoxicity. Isatin hybrids are endowed with an… read more here.
Keywords: novel anti; anti tubercular; hybrids novel; repositioning isatin ... See more keywords
Indole-fused spirochromenes as potential anti-tubercular agents: design, synthesis and in vitro evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10108-z
Abstract: As part of an ongoing effort to develop new anti-tubercular agents, a series of novel indole-fused spirochromene hybrids (7a–l) were efficiently synthesized in excellent yields by the popular ‘Fisher–Indole synthesis’ approach. The structure elucidation of… read more here.
Keywords: tubercular agents; fused spirochromenes; anti tubercular; synthesis ... See more keywords
Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra01348j
Abstract: Pyrazinamide is an important first-line drug used in shortening TB therapy. In our current work, a series of novel substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives were designed, synthesized, and evaluated for their anti-tubercular activity against Mycobacterium tuberculosis H37Ra. Among… read more here.
Keywords: substituted pyrazine; tubercular agents; piperazine homopiperazine; anti tubercular ... See more keywords
Indole derivatives as anti-tubercular agents: An overview on their synthesis and biological activities.
Sign Up to like & getrecommendations! Published in 2020 at "Current medicinal chemistry"
DOI: 10.2174/0929867327666200918144709
Abstract: BACKGROUND The indole framework is considered as one of the privileged structures in the area of medicinal chemistry and drug discovery because compounds containing this framework have shown to possess remarkable ability to bind with… read more here.
Keywords: chemistry; tubercular activities; tubercular agents; indole derivatives ... See more keywords
An insight on the prospect of quinazoline and quinazolinone derivatives as anti-tubercular agents.
Sign Up to like & getrecommendations! Published in 2023 at "Current organic synthesis"
DOI: 10.2174/1570179420666230316094435
Abstract: Multiple potential drugs have been developed based on the heterocyclic molecules for the treatment of different symptoms. Among the existing heterocyclic molecules, quinazoline and quinazolinone derivatives have been found to exhibit extensive pharmacological and biological… read more here.
Keywords: anti tubercular; quinazoline quinazolinone; quinazolinone derivatives; insight prospect ... See more keywords
The Follow-up of 360 Patients with Pulmonary Tuberculosis After 2 Months Treatment With Anti-tubercular Agents in Iran
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Clinical Infectious Diseases"
DOI: 10.5812/archcid.62132
Abstract: Background: Tuberculosis (TB) is a major global health problem. The goal is to end the global TB epidemic. TB treatment averted 49 million deaths globally from 2000 to 2015. If everyone with TB had a… read more here.
Keywords: treatment; treatment anti; drug; tubercular agents ... See more keywords