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   Articles with "tuberculosis" as a keyword



Association of Mortality and Years of Potential Life Lost With Active Tuberculosis in the United States

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recommendations! Published in 2020 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2020.14481

Abstract: This cohort study examines the risk of mortality and years of potential life lost among patients with active tuberculosis disease compared with individuals without active tuberculosis. read more here.

Keywords: mortality years; years potential; active tuberculosis; tuberculosis ... See more keywords

In-Person vs Electronic Directly Observed Therapy for Tuberculosis Treatment Adherence

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recommendations! Published in 2022 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2021.44210

Abstract: Key Points Question Is electronic directly observed therapy (DOT) noninferior to in-person DOT in supporting medication adherence for tuberculosis treatment? Findings In this randomized, 2-period crossover noninferiority trial of 216 patients with tuberculosis, the modified… read more here.

Keywords: tuberculosis; directly observed; electronic directly; dot ... See more keywords

Comparison of Tuberculin Skin Testing and Interferon-γ Release Assays in Predicting Tuberculosis Disease

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recommendations! Published in 2024 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2024.4769

Abstract: Key Points Question What is the relative performance of 3 clinically available tuberculosis (TB) tests in predicting TB disease development in the low-incidence setting of the US? Findings In this diagnostic study of 22 020 participants,… read more here.

Keywords: release assays; disease; tuberculosis; interferon release ... See more keywords

Clinicopathologic Features of Tuberculous Serpiginous-like Choroiditis.

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recommendations! Published in 2018 at "JAMA ophthalmology"

DOI: 10.1001/jamaophthalmol.2017.5791

Abstract: Clinicopathologic Features of Tuberculous Serpiginous-like Choroiditis Serpiginous-like choroiditis (SLC) is a choroidal inflammation of diverse causes, which clinically resembles serpiginous choroiditis.1 Intraocular tuberculosis commonly presents as SLC in countries where Mycobacterium tuberculosis is endemic. In… read more here.

Keywords: choroiditis; serpiginous like; tuberculosis; like choroiditis ... See more keywords

Sensitive and Feasible Specimen Collection and Testing Strategies for Diagnosing Tuberculosis in Young Children.

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recommendations! Published in 2021 at "JAMA pediatrics"

DOI: 10.1001/jamapediatrics.2020.6069

Abstract: Importance Criterion-standard specimens for tuberculosis diagnosis in young children, gastric aspirate (GA) and induced sputum, are invasive and rarely collected in resource-limited settings. A far less invasive approach to tuberculosis diagnostic testing in children younger… read more here.

Keywords: reference; tuberculosis; sensitivity interdecile; yield ... See more keywords

Mn and Zn‐Doped Multivariate Metal–Organic Framework as a Metalloimmunological Adjuvant to Promote Protection Against Tuberculosis Infection

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recommendations! Published in 2024 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202402358

Abstract: A first‐in‐class vaccine adjuvant delivery system, Mn‐ZIF, is developed by incorporating manganese (Mn) into the zinc‐containing zeolitic‐imidazolate framework‐8 (ZIF‐8). The mixed metal approach, which allowed for tunable Mn doping, is made possible by including a… read more here.

Keywords: framework; tuberculosis; metal; cda ... See more keywords

NIR‐II AIE Luminogen‐Based Erythrocyte‐Like Nanoparticles with Granuloma‐Targeting and Self‐Oxygenation Characteristics for Combined Phototherapy of Tuberculosis

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recommendations! Published in 2024 at "Advanced Materials"

DOI: 10.1002/adma.202406143

Abstract: Tuberculosis, a fatal infectious disease caused by Mycobacterium tuberculosis (M.tb), is difficult to treat with antibiotics due to drug resistance and short drug half‐life. Phototherapy represents a promising alternative to antibiotics in combating M.tb. Exploring… read more here.

Keywords: granuloma; granuloma targeting; tuberculosis; targeting self ... See more keywords

Pyrrole‐Thiazolidin‐4‐one Analogues Exhibit Promising Anti‐Tuberculosis Activity

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recommendations! Published in 2024 at "Asian Journal of Organic Chemistry"

DOI: 10.1002/ajoc.202400054

Abstract: A series of pyrrole‐thiazolidin‐4‐one conjugates were synthesized and evaluated for their anti‐mycobacterial and anti‐bacterial activities. Two compounds, 10a and 10k were the most effective conjugates and produced identical MICs (0.5 µg/mL) against M. tuberculosis H37Rv… read more here.

Keywords: pyrrole thiazolidin; tuberculosis; one analogues; analogues exhibit ... See more keywords

A Test Case for the Synthesis of a Hybrid 6‐(pyrazolyl)‐indole Molecules: Anti‐tuberculosis Evaluations and In‐silico Studies

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recommendations! Published in 2024 at "Asian Journal of Organic Chemistry"

DOI: 10.1002/ajoc.202400165

Abstract: In this study, we synthesized and characterized various 6‐(pyrazolyl)‐indole derivatives and characterized using spectroscopic techniques. Substituents including electron‐withdrawing (formyl, nitrile, carboxylic acid, ester, amide, nitro) and donating groups (methylene alcohol, chloro) were introduced at the… read more here.

Keywords: pyrazolyl indole; test case; anti tuberculosis; case synthesis ... See more keywords

Synthesis, in vitro antibacterial activity against Mycobacterium tuberculosis, and reverse docking‐based target fishing of 1,4‐benzoxazin‐2‐one derivatives

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recommendations! Published in 2021 at "Archiv der Pharmazie"

DOI: 10.1002/ardp.202000199

Abstract: Seventeen 1,4‐benzoxazin‐2‐ones bearing the enaminone moiety and three of their analogs were tested for the antibacterial activity against Mycobacterium tuberculosis (H37Rv). Minimal bactericidal concentrations (MBCs) were determined after 41 days of incubation by BACTEC. 1,4‐Benzoxazin‐2‐ones… read more here.

Keywords: antibacterial activity; tuberculosis; activity mycobacterium; reverse docking ... See more keywords

Drug re‐engineering and repurposing: A significant and rapid approach to tuberculosis drug discovery

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recommendations! Published in 2022 at "Archiv der Pharmazie"

DOI: 10.1002/ardp.202200214

Abstract: The prevalence of tuberculosis (TB) remains the leading cause of death from a single infectious agent, ranking it above all other contagious diseases. The problem to tackle this disease seems to become even worse due… read more here.

Keywords: drug discovery; tuberculosis; classes compounds; drug development ... See more keywords