Detecting Mycobacterium tuberculosis complex and rifampicin resistance via a new rapid multienzyme isothermal point mutation assay.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2021.114341
Abstract: Simple, rapid, and accurate detection of the Mycobacterium tuberculosis complex (MTBC) and drug resistance is critical for improving patient care and decreasing the spread of tuberculosis. To this end, we have developed a new simple… read more here.
Keywords: multienzyme isothermal; tuberculosis complex; rif resistance; tuberculosis ... See more keywords
Low antimicrobial resistance rates of Mycobacterium tuberculosis complex between 2000 and 2015 in Gipuzkoa, northern Spain.
Sign Up to like & getrecommendations! Published in 2019 at "Enfermedades infecciosas y microbiologia clinica"
DOI: 10.1016/j.eimc.2019.01.016
Abstract: OBJECTIVE Although the incidence of tuberculosis (TB) has declined, TB drug resistance remains a major problem. The TB rate in Gipuzkoa (northern Spain) is higher than the European average. The objective of this study was… read more here.
Keywords: northern spain; gipuzkoa northern; tuberculosis complex; tuberculosis ... See more keywords
Differentiation of live and dead Mycobacterium tuberculosis complex in meat samples using PMA qPCR.
Sign Up to like & getrecommendations! Published in 2019 at "Food microbiology"
DOI: 10.1016/j.fm.2019.103275
Abstract: The causative agents of zoonotic bovine tuberculosis (bTB), Mycobacterium bovis and M. caprae, are members of the M. tuberculosis complex (MTC). Wildlife such as red deer infected with bTB are often without pathological findings, thus… read more here.
Keywords: pma qpcr; meat; meat samples; tuberculosis complex ... See more keywords
Rapid and visual detection of Mycobacterium tuberculosis complex using recombinase polymerase amplification combined with lateral flow strips.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2017.08.004
Abstract: To definitively diagnose active pulmonary Tuberculosis (TB), Mycobacterium tuberculosis complex (MTBC) bacilli must be identified within clinical specimens from patients. In this study, we introduced a rapid and visual detection method of MTBC using recombinase… read more here.
Keywords: detection; visual detection; tuberculosis complex; tuberculosis ... See more keywords
Evolution of virulence in the Mycobacterium tuberculosis complex.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2017.11.021
Abstract: Mycobacterium tuberculosis, the causative agent of human tuberculosis is one of the most widely spread human pathogens. It has succeeded to infect a quarter of the global human population by developing most sophisticated ways to… read more here.
Keywords: mycobacterium; evolution; virulence; tuberculosis complex ... See more keywords
New assay to diagnose and differentiate between Mycobacterium tuberculosis complex and nontuberculous mycobacteria.
Sign Up to like & getrecommendations! Published in 2019 at "Tuberculosis"
DOI: 10.1016/j.tube.2018.10.004
Abstract: The purpose of the present study was to create a real-time PCR test system allowing simultaneous detection of nontuberculous mycobacteria (NTM) and Mycobacterium tuberculosis complex (MTBC) both in culture and sputum. NTM cultures (18 strains,… read more here.
Keywords: nontuberculous mycobacteria; tuberculosis complex; culture sputum; tuberculosis ... See more keywords
Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11948-6
Abstract: The Mycobacterium tuberculosis complex (MTBC) members display different host-specificities and virulence phenotypes. Here, we have performed a comprehensive RNAseq and methylome analysis of the main clades of the MTBC and discovered unique transcriptional profiles. The… read more here.
Keywords: genome wide; transcriptional profiles; tuberculosis complex; mycobacterium tuberculosis ... See more keywords
Ancient and recent differences in the intrinsic susceptibility of Mycobacterium tuberculosis complex to pretomanid
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkac070
Abstract: Abstract Objectives To develop a robust phenotypic antimicrobial susceptibility testing (AST) method with a correctly set breakpoint for pretomanid (Pa), the most recently approved anti-tuberculosis drug. Methods The Becton Dickinson Mycobacterial Growth Indicator Tube™ (MGIT)… read more here.
Keywords: mycobacterium tuberculosis; tuberculosis; pretomanid; tuberculosis complex ... See more keywords
Changing Incidence and Characteristics of Nontuberculous Mycobacterial Infections in Scotland and Comparison With Mycobacterium tuberculosis Complex Incidence (2011 to 2019)
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac665
Abstract: Abstract Background An increase in infections with nontuberculous mycobacteria (NTM) has been noted globally, and their incidence has overtaken that of Mycobacterium tuberculosis complex (MTBc) in many countries. Using data from a national reference laboratory,… read more here.
Keywords: mycobacterium tuberculosis; incidence; tuberculosis complex; society ... See more keywords
Mycobacterium decipiens sp. nov., a new species closely related to the Mycobacterium tuberculosis complex.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of systematic and evolutionary microbiology"
DOI: 10.1099/ijsem.0.003031
Abstract: Two mycobacterial strains with close similarity to the Mycobacterium tuberculosis complex (MTBC) were isolated from cutaneous lesions of patients in the USA and Italy. At the phenotypic level, similarities to the MTBC included slow growth… read more here.
Keywords: closely related; mycobacterium; new species; tuberculosis complex ... See more keywords
The rate and role of pseudogenes of the Mycobacterium tuberculosis complex
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Genomics"
DOI: 10.1099/mgen.0.000876
Abstract: Whole-genome sequence analyses have significantly contributed to the understanding of virulence and evolution of the Mycobacterium tuberculosis complex (MTBC), the causative pathogens of tuberculosis. Most MTBC evolutionary studies are focused on single nucleotide polymorphisms and… read more here.
Keywords: mycobacterium tuberculosis; predicted pseudogenes; tuberculosis; silico predicted ... See more keywords