Comparison of the predictive outcomes for anti-tuberculosis drug-induced hepatotoxicity by different machine learning techniques
Sign Up to like & getrecommendations! Published in 2020 at "Computer methods and programs in biomedicine"
DOI: 10.1016/j.cmpb.2019.105307
Abstract: BACKGROUND The study compared the predictive outcomes of artificial neural network, support vector machine and random forest on the occurrence of anti-tuberculosis drug-induced hepatotoxicity. METHODS The clinical and genomic data of patients treated with anti-tuberculosis… read more here.
Keywords: machine; induced hepatotoxicity; tuberculosis drug; drug induced ... See more keywords
The present state of the tuberculosis drug development pipeline
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2018.08.001
Abstract: &NA; Tuberculosis now ranks as the leading cause of death in the world due to a single infectious agent. Current standard of care treatment can achieve very high cure rates for drug‐sensitive disease but requires… read more here.
Keywords: tuberculosis drug; pipeline; present state; drug ... See more keywords
Vitamins A and D fail to protect against tuberculosis-drug-induced liver injury: A post hoc analysis of a previous randomized controlled trial.
Sign Up to like & getrecommendations! Published in 2021 at "Nutrition"
DOI: 10.1016/j.nut.2021.111155
Abstract: OBJECTIVES Vitamins A and D provided protection from xenobiotic-induced liver injury in previous animal studies. We conducted a post hoc analysis of our previous randomized controlled trial to investigate the effects of vitamin A and… read more here.
Keywords: tuberculosis drug; induced liver; liver injury; vitamin ... See more keywords
Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery
Sign Up to like & getrecommendations! Published in 2017 at "Accounts of Chemical Research"
DOI: 10.1021/acs.accounts.6b00631
Abstract: Conspectus New, safe and effective drugs are urgently needed to treat and control malaria and tuberculosis, which affect millions of people annually. However, financial return on investment in the poor settings where these diseases are… read more here.
Keywords: drug; malaria tuberculosis; tuberculosis drug; drug discovery ... See more keywords
Synthesis and Testing of Analogs of the Tuberculosis Drug Candidate SQ109 against Bacteria and Protozoa: Identification of Lead Compounds against Mycobacterium abscessus and Malaria Parasites.
Sign Up to like & getrecommendations! Published in 2023 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00537
Abstract: SQ109 is a tuberculosis drug candidate that has high potency against Mycobacterium tuberculosis and is thought to function at least in part by blocking cell wall biosynthesis by inhibiting the MmpL3 transporter. It also has… read more here.
Keywords: tuberculosis; drug candidate; sq109 bacteria; activity ... See more keywords
Targeting MmpL3 for anti-tuberculosis drug development
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Society Transactions"
DOI: 10.1042/bst20190950
Abstract: The unique architecture of the mycobacterial cell envelope plays an important role in Mycobacterium tuberculosis (Mtb) pathogenesis. A critical protein in cell envelope biogenesis in mycobacteria, required for transport of precursors, trehalose monomycolates (TMMs), is… read more here.
Keywords: transport; drug development; mmpl3 anti; tuberculosis drug ... See more keywords
Efflux pump effects on Mycobacterium tuberculosis drug resistance.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemotherapy"
DOI: 10.1080/1120009x.2023.2173857
Abstract: Resistance and tolerance to antituberculosis drugs have become serious problems in disease treatment. This multi-phase study investigated the contributions of efflux pumps to Mycobacterium tuberculosis drug resistance. In the first phase, the minimum inhibitory concentration… read more here.
Keywords: mycobacterium tuberculosis; pump inhibitors; resistance; pump ... See more keywords
Screening differential circular RNA expression profiles reveals the regulatory role of circMARS in anti‐tuberculosis drug‐induced liver injury
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17157
Abstract: Tuberculosis (TB) treatment is plagued by liver damage, which often leads to treatment interruptions. Circular RNAs (circRNAs) are a special class of non‐coding RNAs abundant in body fluids with important biological functions. However, the role… read more here.
Keywords: drug induced; role; anti tuberculosis; liver injury ... See more keywords
Collocating novel targets for Tuberculosis (TB) Drug Discovery.
Sign Up to like & getrecommendations! Published in 2020 at "Current drug discovery technologies"
DOI: 10.2174/1570163817666200121143036
Abstract: BACKGROUND Mycobacterium tuberculosis, being a resistive species is an incessant threat to the world population for the treatment of Tuberculosis (TB). An advanced genetic or a molecular level approach is mandatory for both diagnosis and… read more here.
Keywords: collocating novel; tuberculosis drug; drug; novel targets ... See more keywords
Tuberculosis Drug Discovery: A Decade of Hit Assessment for Defined Targets
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.611304
Abstract: More than two decades have elapsed since the publication of the first genome sequence of Mycobacterium tuberculosis (Mtb) which, shortly thereafter, enabled methods to determine gene essentiality in the pathogen. Despite this, target-based approaches have… read more here.
Keywords: drug discovery; decade; defined targets; tuberculosis drug ... See more keywords
Urine metabolomics and microbiome analyses reveal the mechanism of anti-tuberculosis drug-induced liver injury, as assessed for causality using the updated RUCAM: A prospective study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1002126
Abstract: Background Anti-tuberculosis drug-induced liver injury (ATB-DILI) is one of the most common adverse reactions that brings great difficulties to the treatment of tuberculosis. Thus, early identification of individuals at risk for ATB-DILI is urgent. We… read more here.
Keywords: atb dili; anti tuberculosis; dili; tuberculosis drug ... See more keywords