Identification of covalent inhibitors that disrupt M. tuberculosis growth by targeting multiple serine hydrolases involved in lipid metabolism.
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DOI: 10.1016/j.chembiol.2021.08.013
Abstract: The increasing incidence of antibiotic-resistant Mycobacterium tuberculosis infections is a global health threat necessitating the development of new antibiotics. Serine hydrolases (SHs) are a promising class of targets because of their importance for the synthesis… read more here.
Keywords: covalent inhibitors; identification covalent; serine hydrolases; tuberculosis growth ... See more keywords