A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase
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DOI: 10.1021/acsinfecdis.3c00012
Abstract: The rise in drug-resistant tuberculosis has necessitated the search for alternative antibacterial treatments. Spiropyrimidinetriones (SPTs) represent an important new class of compounds that work through gyrase, the cytotoxic target of fluoroquinolone antibacterials. The present study… read more here.
Keywords: mycobacterium tuberculosis; dna cleavage; tuberculosis; series ... See more keywords