Improved Mycobacterium tuberculosis clearance after the restoration of IFN‐γ+TNF‐α+CD4+T cells: Impact of PD‐1 inhibition in active tuberculosis patients
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DOI: 10.1002/eji.201948283
Abstract: Prolonged therapy, drug toxicity, noncompliance, immune suppression, and alarming emergence of drug resistance necessitate the search for therapeutic vaccine strategies for tuberculosis (TB). Such strategies ought to elicit not only IFN‐γ, but polyfunctional response including… read more here.
Keywords: active tuberculosis; inhibition; tuberculosis patients; impact inhibition ... See more keywords
Platelets accumulate in lung lesions of tuberculosis patients and inhibit T‐cell responses and Mycobacterium tuberculosis replication in macrophages
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149549
Abstract: Platelets regulate human inflammatory responses that lead to disease. However, the role of platelets in tuberculosis (TB) pathogenesis is still unclear. Here, we show that patients with active TB have a high number of platelets… read more here.
Keywords: tuberculosis patients; tuberculosis; lung lesions; accumulate lung ... See more keywords
Analysis of variants in mitochondrial genome and their putative pathogenicity in Tuberculosis patients from Mizoram, North east India.
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DOI: 10.1016/j.mito.2020.06.012
Abstract: Tuberculosis caused by Mycobacterium tuberculosis is one of the main global health concerns. In this study, the entire mitochondrial genome from blood samples of tuberculosis patients was analyzed to understand the possible mtDNA variants. The… read more here.
Keywords: tuberculosis patients; analysis variants; tuberculosis; variants mitochondrial ... See more keywords
Macrodetermined racial inequalities in diagnostic testing among tuberculosis patients in Brazil.
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DOI: 10.1016/j.puhe.2018.11.003
Abstract: OBJECTIVES To estimate the association between tuberculosis (TB) patients' race and patients' access to diagnostic testing in Brazil. In addition, we evaluated if the associations could be explained by a geographic codistribution between racial groups… read more here.
Keywords: tuberculosis patients; diagnostic testing; brazilian patients; afro brazilian ... See more keywords
Underweight increases the risk of early death in tuberculosis patients
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DOI: 10.1017/s0007114517003166
Abstract: Abstract Evidence regarding the association between BMI and mortality in tuberculosis (TB) patients is limited and inconsistent. We investigated the impact of BMI on TB-specific and non-TB-specific mortality with respect to different timing of death.… read more here.
Keywords: death; non specific; tuberculosis patients; mortality ... See more keywords
The change in blood glucose levels in tuberculosis patients before and during anti-tuberculosis treatment in China
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DOI: 10.1080/16549716.2017.1289737
Abstract: ABSTRACT Objective: We aimed to observe (i) changes in fasting blood glucose (FBG) in tuberculosis (TB) patients before and during anti-TB treatment, (ii) whether FBG levels were stable or unstable and (iii) baseline characteristics associated… read more here.
Keywords: fbg mmol; treatment; tuberculosis patients; tuberculosis ... See more keywords
In vitro infection with Mycobacterium tuberculosis induces a distinct immunological pattern in blood from healthy relatives of tuberculosis patients.
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DOI: 10.1093/femspd/ftx109
Abstract: Part of the susceptibility to tuberculosis has a genetic basis, which is clear in primary immunodeficiencies, but is less evident in apparently immunocompetent subjects. Immune responses were analysed in blood samples from tuberculosis patients and… read more here.
Keywords: tuberculosis patients; tuberculosis; relatives tuberculosis; blood ... See more keywords
Development of prognostic scoring system for predicting 1-year mortality among pulmonary tuberculosis patients in South India.
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DOI: 10.1093/pubmed/fdac087
Abstract: BACKGROUND Development of a prediction model using baseline characteristics of tuberculosis (TB) patients at the time of diagnosis will aid us in early identification of the high-risk groups and devise pertinent strategies accordingly. Hence, we… read more here.
Keywords: prognostic scoring; tuberculosis patients; tuberculosis; scoring system ... See more keywords
Tuberculosis patients display a high proportion of CD8+ T cells with a high cytotoxic potential
Sign Up to like & getrecommendations! Published in 2019 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12724
Abstract: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) and remains a major cause of morbidity and mortality worldwide. In the host's immune response system, T cells play a critical role in mediating… read more here.
Keywords: cd8; cd8 cells; tuberculosis patients; healthy donors ... See more keywords
Three cases of oral mucosal tuberculosis in patients on tumour‐necrosis‐factor‐α blockers
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DOI: 10.1111/ajd.13998
Abstract: We present three cases of oral mucosal lesions caused by Mycobacterium tuberculosis in patients treated with anti‐tumour necrosis factor‐α for psoriasis or rheumatoid arthritis. Diagnosis of oral mucosal tuberculosis was not easily established in any… read more here.
Keywords: tuberculosis patients; three cases; oral mucosal; tuberculosis ... See more keywords
Impact of metformin therapy on health‐related quality of life outcomes in tuberculosis patients with diabetes mellitus in India: A prospective study
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DOI: 10.1111/ijcp.13864
Abstract: To assess the impact of metformin use on health‐related quality of life (HRQoL) in tuberculosis (TB) patients who are presented with type 2 diabetes mellitus (T2DM). read more here.
Keywords: impact metformin; tuberculosis patients; health related; diabetes mellitus ... See more keywords