Di-n-butyl phthalate exposure induced abnormal autophagy in renal tubular cells via hedgehog signaling in newborn rats.
Sign Up to like & getrecommendations! Published in 2020 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2020.109189
Abstract: Di-n-butyl phthalate (DBP) is a pollutant that is widely present in the environment. We have previously demonstrated that maternal exposure to DBP resulted in renal fibrosis in offspring, but the underlying mechanism was not well… read more here.
Keywords: hedgehog signaling; exposure; tubular cells; renal tubular ... See more keywords
Ischemia/reperfusion‐associated tubular cells injury in renal transplantation: Can metabolomics inform about mechanisms and help identify new therapeutic targets?
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2017.12.032
Abstract: Graphical abstract Figure. No caption available. &NA; Tubular cells are central targets of ischemia‐reperfusion (I/R) injury in kidney transplantation. Inflammation and metabolic disturbances occurring within these cells are deleterious by themselves but also favor secondary… read more here.
Keywords: tubular cells; transplantation; identify new; ischemia reperfusion ... See more keywords
Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43790
Abstract: Rhubarb and its bioactive component rhein are frequently used for the treatment of chronic kidney diseases (CKD) in eastern Asia countries. However, the potential therapeutic mechanism remains unclear. Autophagy plays an important role in CKD.… read more here.
Keywords: mtor signaling; tubular cells; rat renal; renal fibrosis ... See more keywords
P0131HIGH-DOSE URIC ACID ALTERS CELLULAR PROTEOME, INCREASES INTRACELLULAR ATP, ENHANCES TISSUE REPAIR CAPABILITY AND INCREASES CALCIUM OXALATE CRYSTAL-BINDING CAPABILITY OF RENAL TUBULAR CELLS: IMPLICATIONS TO HYPERURICOSURIA-INDUCED KIDNEY STONE DISEASE
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p0131
Abstract: Hyperuricosuria is well documented to get involved in the pathogenesis of kidney stone disease, especially uric acid (UA) and calcium oxalate (CaOx) types. Nevertheless, hyperuricosuria-induced alterations in renal tubular cells and cascade mechanisms that subsequently… read more here.
Keywords: capability; tubular cells; stone disease; kidney stone ... See more keywords
Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13741
Abstract: Proximal tubular (PT) cells reabsorb most calcium (Ca2+), phosphate (PO43−), bicarbonate (HCO3−), and oxalate (C2O42−) ions. We have shown that mice lacking Transient Receptor Potential Canonical 3 (TRPC3−/−) channel are moderately hypercalciuric with presentation of… read more here.
Keywords: tubular cells; proximal tubular; cap; mice ... See more keywords
Induction of ferroptosis selectively eliminates senescent tubular cells
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Transplantation"
DOI: 10.1111/ajt.17102
Abstract: The accumulation of senescent cells is an important contributor to kidney aging, chronic renal disease, and poor outcome after kidney transplantation. Approaches to eliminate senescent cells with senolytic compounds have been proposed as novel strategies… read more here.
Keywords: tubular cells; kidney; senescent cells; ferroptosis ... See more keywords
Expression of cleaved caspase‐3 in renal tubular cells in Plasmodium falciparum malaria patients
Sign Up to like & getrecommendations! Published in 2017 at "Nephrology"
DOI: 10.1111/nep.12715
Abstract: In Plasmodium falciparum malaria, the clinical manifestation of acute kidney injury (AKI) is commonly associated with acute tubular necrosis (ATN) in the kidney tissues. Renal tubular cells often exhibit various degrees of cloudy swelling, cell… read more here.
Keywords: expression cleaved; tubular cells; plasmodium falciparum; falciparum malaria ... See more keywords
Upregulation of TLR4 via PKC activation contributes to impaired wound healing in high-glucose-treated kidney proximal tubular cells
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0178147
Abstract: Acute kidney injury (AKI) leads to a worse prognosis in diabetic patients compared with prognoses in non-diabetic patients, but whether and how diabetes affects kidney repair after AKI remains unknown. Here, we used scratch-wound healing… read more here.
Keywords: wound healing; glucose treated; glucose; tubular cells ... See more keywords
High glucose induces an activated state of partial epithelial-mesenchymal transition in human primary tubular cell cultures
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0279655
Abstract: Tubulointerstitial fibrosis is observed in diabetic nephropathy. It is still debated whether tubular cells, undergoing epithelial-mesenchymal transition (EMT) in high glucose (HG) conditions, may contribute to interstitial fibrosis development. In this study, we investigated the… read more here.
Keywords: cell; tubular cells; primary tubular; mesenchymal transition ... See more keywords
Phosphorylation by GSK-3β increases the stability of SIRT6 to alleviate TGF-β-induced fibrotic response in renal tubular cells.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.2139/ssrn.4148154
Abstract: AIMS The deacetylase Sirtuin 6 (SIRT6) is up-regulated during fibrogenesis in renal tubular cells and post-ischemia/reperfusion kidneys. Hence, our aim was to investigate the mechanism of SIRT6 up-regulation upon profibrotic stress. MAIN METHODS Immunohistochemical staining… read more here.
Keywords: tubular cells; tgf; renal tubular; sirt6 ... See more keywords
SARS-CoV-2 Causes Acute Kidney Injury by Directly Infecting Renal Tubules
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.664868
Abstract: Acute kidney injury (AKI) is one of the most prevalent complications among hospitalized coronavirus disease 2019 (COVID-19) patients. Here, we aim to investigate the causes, risk factors, and outcomes of AKI in COVID-19 patients. We… read more here.
Keywords: kidney injury; tubular cells; acute kidney; sars cov ... See more keywords