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   Articles with "tubular cells" as a keyword



Di-n-butyl phthalate exposure induced abnormal autophagy in renal tubular cells via hedgehog signaling in newborn rats.

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recommendations! Published in 2020 at "Chemico-biological interactions"

DOI: 10.1016/j.cbi.2020.109189

Abstract: Di-n-butyl phthalate (DBP) is a pollutant that is widely present in the environment. We have previously demonstrated that maternal exposure to DBP resulted in renal fibrosis in offspring, but the underlying mechanism was not well… read more here.

Keywords: hedgehog signaling; exposure; tubular cells; renal tubular ... See more keywords

Ischemia/reperfusion‐associated tubular cells injury in renal transplantation: Can metabolomics inform about mechanisms and help identify new therapeutic targets?

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recommendations! Published in 2018 at "Pharmacological Research"

DOI: 10.1016/j.phrs.2017.12.032

Abstract: Graphical abstract Figure. No caption available. &NA; Tubular cells are central targets of ischemia‐reperfusion (I/R) injury in kidney transplantation. Inflammation and metabolic disturbances occurring within these cells are deleterious by themselves but also favor secondary… read more here.

Keywords: tubular cells; transplantation; identify new; ischemia reperfusion ... See more keywords

Vitamin K2 Attenuates Mitochondrial Damage in Renal Proximal Tubular Cells.

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recommendations! Published in 2025 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.5c01320

Abstract: Excessive reactive oxygen species (ROS) levels cause oxidative stress, which can lead to various diseases. Renal failure is associated with oxidative stress and mitochondrial dysfunction. Vitamin K1 (phylloquinone) and K2 (menaquinone) are essential for blood… read more here.

Keywords: renal proximal; damage; tubular cells; oxidative stress ... See more keywords

Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep43790

Abstract: Rhubarb and its bioactive component rhein are frequently used for the treatment of chronic kidney diseases (CKD) in eastern Asia countries. However, the potential therapeutic mechanism remains unclear. Autophagy plays an important role in CKD.… read more here.

Keywords: mtor signaling; tubular cells; rat renal; renal fibrosis ... See more keywords
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P0131HIGH-DOSE URIC ACID ALTERS CELLULAR PROTEOME, INCREASES INTRACELLULAR ATP, ENHANCES TISSUE REPAIR CAPABILITY AND INCREASES CALCIUM OXALATE CRYSTAL-BINDING CAPABILITY OF RENAL TUBULAR CELLS: IMPLICATIONS TO HYPERURICOSURIA-INDUCED KIDNEY STONE DISEASE

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recommendations! Published in 2020 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfaa142.p0131

Abstract: Hyperuricosuria is well documented to get involved in the pathogenesis of kidney stone disease, especially uric acid (UA) and calcium oxalate (CaOx) types. Nevertheless, hyperuricosuria-induced alterations in renal tubular cells and cascade mechanisms that subsequently… read more here.

Keywords: capability; tubular cells; stone disease; kidney stone ... See more keywords

Ablation of TRPC3 compromises bicarbonate and phosphate transporter activity in mice proximal tubular cells

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recommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"

DOI: 10.1111/1440-1681.13741

Abstract: Proximal tubular (PT) cells reabsorb most calcium (Ca2+), phosphate (PO43−), bicarbonate (HCO3−), and oxalate (C2O42−) ions. We have shown that mice lacking Transient Receptor Potential Canonical 3 (TRPC3−/−) channel are moderately hypercalciuric with presentation of… read more here.

Keywords: tubular cells; proximal tubular; cap; mice ... See more keywords

Induction of ferroptosis selectively eliminates senescent tubular cells

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recommendations! Published in 2022 at "American Journal of Transplantation"

DOI: 10.1111/ajt.17102

Abstract: The accumulation of senescent cells is an important contributor to kidney aging, chronic renal disease, and poor outcome after kidney transplantation. Approaches to eliminate senescent cells with senolytic compounds have been proposed as novel strategies… read more here.

Keywords: tubular cells; kidney; senescent cells; ferroptosis ... See more keywords

Proteinuria and tubular cells: Plasticity and toxicity

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recommendations! Published in 2025 at "Acta Physiologica"

DOI: 10.1111/apha.14263

Abstract: Proteinuria is the most robust predictive factors for the progression of chronic kidney disease (CKD), and interventions targeting proteinuria reduction have shown to be the most effective nephroprotective treatments to date. While glomerular dysfunction is… read more here.

Keywords: cells plasticity; tubular cells; plasticity toxicity; proteinuria tubular ... See more keywords

Expression of cleaved caspase‐3 in renal tubular cells in Plasmodium falciparum malaria patients

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recommendations! Published in 2017 at "Nephrology"

DOI: 10.1111/nep.12715

Abstract: In Plasmodium falciparum malaria, the clinical manifestation of acute kidney injury (AKI) is commonly associated with acute tubular necrosis (ATN) in the kidney tissues. Renal tubular cells often exhibit various degrees of cloudy swelling, cell… read more here.

Keywords: expression cleaved; tubular cells; plasmodium falciparum; falciparum malaria ... See more keywords

Metallic and metallic oxide nanoparticles toxicity primarily targets the mitochondria of hepatocytes and renal cells

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recommendations! Published in 2024 at "Toxicology and Industrial Health"

DOI: 10.1177/07482337241282860

Abstract: Nanoparticles (NPs) are utilized in various applications, posing potential risks to human health, tissues, cells, and macromolecules. This study aimed to investigate the ultrastructural alterations in hepatocytes and renal tubular cells induced by metallic and… read more here.

Keywords: nanoparticles toxicity; oxide nps; metallic metallic; tubular cells ... See more keywords

Upregulation of TLR4 via PKC activation contributes to impaired wound healing in high-glucose-treated kidney proximal tubular cells

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0178147

Abstract: Acute kidney injury (AKI) leads to a worse prognosis in diabetic patients compared with prognoses in non-diabetic patients, but whether and how diabetes affects kidney repair after AKI remains unknown. Here, we used scratch-wound healing… read more here.

Keywords: wound healing; glucose treated; glucose; tubular cells ... See more keywords