Protective effect of retinoic acid receptor α on hypoxia‐induced epithelial to mesenchymal transition of renal tubular epithelial cells associated with TGF‐β/MMP‐9 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.10982
Abstract: Retinoic acid receptor α (RARα), a member of family of the nuclear retinoic acid receptors (RARs), plays an essential role in various chronic kidney diseases (CKD). Renal tubular epithelial to mesenchymal transition (EMT) is a… read more here.
Keywords: tgf mmp; retinoic acid; renal tubular; tubular epithelial ... See more keywords
IL‐1β functionally attenuates ABCG2 and PDZK1 expression in HK‐2 cells partially through NF‐ĸB activation
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11100
Abstract: Long‐standing untreated hyperuricemia could lead to gout. Several recent studies have demonstrated a significant decrease of serum urate during acute gout attack, which is an aseptic inflammation process focusing on IL‐1β. However, how IL‐1β, by… read more here.
Keywords: epithelial cells; attenuates abcg2; renal tubular; expression ... See more keywords
microRNA‐486‐5p is implicated in the cisplatin‐induced apoptosis and acute inflammation response of renal tubular epithelial cells by targeting HAT1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23039
Abstract: The proinflammatory property of cisplatin is potentially destructive and contributes to the pathogenesis of acute kidney injury (AKI). The role and upstream regulatory mechanism of histone acetyltransferase 1 (HAT1) in acute kidney inflammation are still… read more here.
Keywords: inflammation; cisplatin induced; hat1; tubular epithelial ... See more keywords
Ox-LDL aggravates contrast-induced injury of renal tubular epithelial cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23379
Abstract: Hypercholesterolemia can aggravate contrast-induced acute kidney injury, and the exacerbation of renal tubular epithelial cell (RTEC) injury is a major cause. However, the exact mechanisms remain obscure. Mitophagy, a type of autophagy, selectively eliminates damaged… read more here.
Keywords: induced injury; contrast induced; renal tubular; mitophagy ... See more keywords
Protein Network Analysis and Functional Studies of Calcium Oxalate Crystal‐Induced Cytotoxicity in Renal Tubular Epithelial Cells
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DOI: 10.1002/pmic.201800008
Abstract: Our previous expression study has reported a set of proteins with altered levels in renal tubular cells after exposure to calcium oxalate monohydrate (COM) crystals, which are the main composition of kidney stones. However, their… read more here.
Keywords: protein network; analysis; renal tubular; calcium oxalate ... See more keywords
Quercetin inhibits the amphiregulin/EGFR signaling‐mediated renal tubular epithelial‐mesenchymal transition and renal fibrosis in obstructive nephropathy
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7599
Abstract: Quercetin is a widely distributed, bioactive flavonoid compound, which displays potential to inhibit fibrosis in several diseases. The purpose of our study was to determine the effect of quercetin treatment on renal fibrosis and investigate… read more here.
Keywords: renal fibrosis; quercetin inhibits; egfr signaling; tubular epithelial ... See more keywords
How Tubular Epithelial Cell Injury Contributes to Renal Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8871-2_11
Abstract: The renal tubules are the major component of the kidney and are vulnerable to a variety of injuries including ischemia, proteinuria, toxins, and metabolic disorders. It has long been believed that tubules are the victim… read more here.
Keywords: epithelial cell; cell injury; fibrosis; cell ... See more keywords
Epigenetic activation of CTGF transcription by high glucose in renal tubular epithelial cells is mediated by myocardin-related transcription factor A
Sign Up to like & getrecommendations! Published in 2019 at "Cell and Tissue Research"
DOI: 10.1007/s00441-019-03124-5
Abstract: Diabetic nephropathy (DN) is one of the most devastating complications of diabetes. Connective tissue growth factor (CTGF) levels are up-regulated in patients with DN and in renal tubular epithelial cells (RTECs) exposed to high glucose… read more here.
Keywords: transcription; factor; renal tubular; tubular epithelial ... See more keywords
Protection of tubular epithelial cells during renal injury via post-transcriptional control of BMP7
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DOI: 10.1007/s11010-017-3063-4
Abstract: Severe injury of renal tubular epithelial cells may cause acute renal failure, the progression of which results in renal fibrosis, and obstructive nephropathy. Transforming growth factor β 1 and bone morphogenic protein 7 (BMP7) play… read more here.
Keywords: epithelial cells; mir 384; renal injury; tubular epithelial ... See more keywords
Preconditioning of primary human renal proximal tubular epithelial cells without tryptophan increases survival under hypoxia by inducing autophagy
Sign Up to like & getrecommendations! Published in 2017 at "International Urology and Nephrology"
DOI: 10.1007/s11255-017-1596-9
Abstract: PurposeHypoxia plays a significant role in the pathogenesis of acute kidney injury (AKI). Autophagy protects from AKI. Amino acid deprivation induces autophagy. The effect of l-tryptophan depletion on survival and autophagy in cultures of renal… read more here.
Keywords: renal proximal; without tryptophan; tryptophan; autophagy ... See more keywords
Epstein-Barr virus-encoded latent membrane protein 1 induces epithelial to mesenchymal transition by inducing V-set Ig domain containing 4 (VSIG4) expression via NF-kB in renal tubular epithelial HK-2 cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.08.116
Abstract: The epithelial to mesenchymal transition (EMT), a hallmark of chronic kidney disease, is a key event in the conversion from tubular epithelial cells to myofibroblasts in renal fibrosis. Epstein-Barr virus (EBV) is a γ-herpes oncovirus… read more here.
Keywords: epithelial cells; mesenchymal transition; epstein barr; lmp1 ... See more keywords