Acute Tubular Injury and Renal Arterial Myocyte Vacuolization Following Crizotinib Administration
Sign Up to like & getrecommendations! Published in 2021 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2020.11.029
Abstract: INTRODUCTION C onsiderable part (19.4%) of the total cancer deaths (1.59 million deaths worldwide) in 2012 were related to lung cancer. It is estimated that more than 200,000 new cases of lung cancer will develop… read more here.
Keywords: acute tubular; tubular injury; myocyte vacuolization; lung cancer ... See more keywords
Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2016.09.003
Abstract: Few investigations have evaluated the incremental usefulness of tubular injury biomarkers for improved prediction of chronic kidney disease (CKD) progression. As such, we measured urinary kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, N-acetyl-ß-D-glucosaminidase and liver fatty acid… read more here.
Keywords: tubular injury; clinical model; disease; progression ... See more keywords
Protective Role of Apelin Against Cyclosporine-Induced Renal Tubular Injury in Rats.
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2017.03.080
Abstract: BACKGROUND Cyclosporine (CsA) usually reduces glomerular filtration rate (GFR) but also can induce tubular injury without resulting in GFR reduction. Apelin is an endogenous ligand for the apelin receptor and has diverse physiologic roles related… read more here.
Keywords: tubular injury; apelin; renal tubular; csa induced ... See more keywords
Molecular nephrology: types of acute tubular injury
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Nephrology"
DOI: 10.1038/s41581-019-0184-x
Abstract: The acute loss of kidney function has been diagnosed for many decades using the serum concentration of creatinine — a muscle metabolite that is an insensitive and non-specific marker of kidney function, but is now… read more here.
Keywords: kidney injury; nephrology; tubular injury; function ... See more keywords
Dapagliflozin Ameliorates Renal Tubular Ferroptosis in Diabetes via SLC40A1 Stabilization
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9735555
Abstract: Tubular injury has been shown to play a critical role in the morbidity of diabetic kidney disease (DKD); ferroptosis often occurs in tubules during renal disease development. This study was aimed at evaluating the inhibitory… read more here.
Keywords: via slc40a1; slc40a1 stabilization; ferroptosis; tubular injury ... See more keywords
Protective Effects of Glucagon-Like Peptide-1 Analog on Renal Tubular Injury in Mice on High-Fat Diet
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000464118
Abstract: Aims: The study aimed to investigate the renoprotective effect of glucagon-like peptide-1 (GLP-1) against renal tubular injury in C57BL/6 mice induced by a high-fat diet (HFD). Methods: Twenty C57BL/6 mice were fed HFD for 12… read more here.
Keywords: glucagon like; tubular injury; treatment; renal tubular ... See more keywords
Weight-gain induced changes in renal perfusion assessed by contrast-enhanced ultrasound precede increases in urinary protein excretion suggestive of glomerular and tubular injury and normalize after weight-loss in dogs
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0231662
Abstract: Early detection of obesity-related glomerulopathy in humans is challenging as it might not be detected by routine biomarkers of kidney function. This study’s aim was to use novel kidney biomarkers and contrast-enhanced ultrasound (CEUS) to… read more here.
Keywords: glomerular tubular; tubular injury; perfusion; weight loss ... See more keywords
Hyperuricemia Induces Wnt5a/Ror2 Gene Expression, Epithelial–Mesenchymal Transition, and Kidney Tubular Injury in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Iranian Journal of Medical Sciences"
DOI: 10.30476/ijms.2018.40525
Abstract: Background Hyperuricemia contributes to kidney injury, characterized by tubular injury with epithelial–mesenchymal transition (EMT). Wnt5a/Ror2 signaling drives EMT in many kidney pathologies. This study sought to evaluate the involvement of Wnt5a/Ror2 in hyperuricemia-induced EMT in… read more here.
Keywords: uric acid; tubular injury; wnt5a ror2; expression ... See more keywords
Motile Cilia on Kidney Proximal Tubular Epithelial Cells Are Associated With Tubular Injury and Interstitial Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.765887
Abstract: It is well established that mammalian kidney epithelial cells contain a single non-motile primary cilium (9 + 0 pattern). However, we noted the presence of multiple motile cilia with a central microtubular pair (9 +… read more here.
Keywords: motile cilia; tubular injury; injury; kidney ... See more keywords
Immune-related SERPINA3 as a biomarker involved in diabetic nephropathy renal tubular injury
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.979995
Abstract: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease and has become a serious medical issue globally. Although it is known to be associated with glomerular injury, tubular injury has been found to… read more here.
Keywords: renal tubular; immune related; injury; gene ... See more keywords
Using random forest algorithm for glomerular and tubular injury diagnosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.911737
Abstract: Objectives Chronic kidney disease (CKD) is a common chronic condition with high incidence and insidious onset. Glomerular injury (GI) and tubular injury (TI) represent early manifestations of CKD and could indicate the risk of its… read more here.
Keywords: diagnosis; ckd; random forest; explanatory variables ... See more keywords