Binding of alpha‐fodrin to gamma‐tubulin accounts for its role in the inhibition of microtubule nucleation
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13425
Abstract: Non‐erythroid spectrin or fodrin is present as part of the γ‐tubulin ring complex (γ‐TuRC) in brain tissue and brain derived cells. Here, we show that fodrin, which is otherwise known for providing structural support to… read more here.
Keywords: microtubule nucleation; nucleation; gamma tubulin; tubulin ... See more keywords
Identification of optimal reference genes in Bombyx mori (Lepidoptera) for normalization of stress-responsive genes after challenge with pesticides.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21896
Abstract: Pesticides are frequently used to control pests in agriculture due to their ease of use and effectiveness, but their use causes serious economic losses to sericulture when their production overlaps with agriculture. However, no suitable… read more here.
Keywords: reference genes; relatively stable; bmgapdh tubulin; tubulin ... See more keywords
New 3‐Substituted‐2‐(4‐hydroxyanilino)pyridine Derivatives: Synthesis, Antitumor Activity, and Tubulin Polymerization Inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201600256
Abstract: A series of new pyridine derivatives 4a–c, 5a–d, 6a–d, 7a–f, and 8a–f structurally related to ABT‐751 were synthesized and characterized by spectroscopic means and elemental analysis. All the synthesized compounds were tested for their cytotoxic… read more here.
Keywords: new substituted; inhibition; substituted hydroxyanilino; tubulin ... See more keywords
Chemical Proteomics Reveals Protein Tyrosination Extends Beyond the Alpha‐Tubulins in Human Cells
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200414
Abstract: Tubulin detyrosination-tyrosination cycle regulates the stability of microtubules. Thus far described on α-tubulins, the tyrosination level is maintained by a single tubulin-tyrosine ligase (TTL). However, the precise dynamics and tubulin isoforms which undergo (de)tyrosination in… read more here.
Keywords: tyrosine; tyrosination; reveals protein; chemical proteomics ... See more keywords
Proper cytoskeleton α‐tubulin distribution is concomitant to tyrosine phosphorylation during in vitro capacitation and acrosomal reaction in human spermatozoa
Sign Up to like & getrecommendations! Published in 2020 at "Cytoskeleton"
DOI: 10.1002/cm.21631
Abstract: Spermatozoa motility is a key parameter during the fertilization process. In this context, spermatozoa tyrosine protein phosphorylation and an appropriate cytoskeleton α‐tubulin distribution are some of the most important physiological events involved in motility. However,… read more here.
Keywords: spermatozoa; capacitation; tyrosine; tubulin ... See more keywords
Microtubule‐associated proteins and enzymes modifying tubulin
Sign Up to like & getrecommendations! Published in 2023 at "Cytoskeleton"
DOI: 10.1002/cm.21748
Abstract: Microtubules (MTs) are essential for many cellular processes including establishment of cell shape and polarity, chromosome segregation, vesicle transport, and nuclear positioning. Human cells express 22 tubulin isoforms that have both overlapping and distinctive functions.… read more here.
Keywords: microtubule associated; tubulin; enzymes modifying; proteins enzymes ... See more keywords
Effects of the Protonation State of Titratable Residues and the Presence of Water Molecules on Nocodazole Binding to β‐Tubulin
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201700530
Abstract: Regulation of microtubule assembly by antimitotic agents is a potential therapeutic strategy for the treatment of cancer, parasite infections, and neurodegenerative diseases. One of these agents is nocodazole (NZ), which inhibits microtubule polymerization by binding… read more here.
Keywords: state; water molecules; binding tubulin; protonation ... See more keywords
Alpha‐ and beta‐tubulin isotypes are differentially expressed during brain development
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22745
Abstract: Alpha‐ and beta‐tubulin dimers polymerize into protofilaments that associate laterally to constitute a hollow tube, the microtubule. A dynamic network of interlinking filaments forms the microtubule cytoskeleton, which maintains the structure of cells and is… read more here.
Keywords: tubulin isotypes; tubulin; alpha beta; beta tubulin ... See more keywords
Tubulin–Na+ ,K +‐ATPase interaction: Involvement in enzymatic regulation and cellular function
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27610
Abstract: A new function for tubulin was described by our laboratory: acetylated tubulin forms a complex with Na+,K +‐ATPase (NKA) and inhibits its activity. This process was shown to be a regulatory factor of physiological importance… read more here.
Keywords: acetylated tubulin; atpase; physiology; function ... See more keywords
Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21541
Abstract: Tubulin, the microtubules and their dynamic behavior are amongst the most successful antitumor, antifungal, antiparasitic, and herbicidal drug targets. Sulfonamides are exemplary drugs with applications in the clinic, in veterinary and in the agrochemical industry.… read more here.
Keywords: combination; target; drug; sulfonamides successful ... See more keywords
Insights into allosteric control of microtubule dynamics from a buried β‐tubulin mutation that causes faster growth and slower shrinkage
Sign Up to like & getrecommendations! Published in 2020 at "Protein Science"
DOI: 10.1002/pro.3842
Abstract: αβ‐tubulin subunits cycle through a series of different conformations in the polymer lattice during microtubule growing and shrinking. How these allosteric responses to different tubulin:tubulin contacts contribute to microtubule dynamics, and whether the contributions are… read more here.
Keywords: microtubule; allosteric control; microtubule dynamics; tubulin ... See more keywords