Rutin increases alpha-tubulin acetylation via histone deacetylase 6 inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Drug development research"
DOI: 10.1002/ddr.21927
Abstract: Microtubules are dynamic cytoskeletal filaments composed of alpha- (α) and beta (β)-tubulin proteins. α-tubulin proteins are posttranslationally acetylated, and loss of acetylation is associated with axonal transport defects, a common alteration contributing to the pathomechanisms… read more here.
Keywords: tubulin acetylation; increases alpha; inhibition; rutin increases ... See more keywords
Tubulin acetylation promotes penetrative capacity of cells undergoing radial intercalation
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109556
Abstract: SUMMARY Post-translational modification of tubulin provides differential functions to microtubule networks. Here, we address the role of tubulin acetylation on the penetrative capacity of cells undergoing radial intercalation, which is the process by which cells… read more here.
Keywords: acetylation; capacity cells; tubulin acetylation; penetrative capacity ... See more keywords
Mass Spectrometric Quantitation of Tubulin Acetylation from Pepsin-Digested Rat Brain Tissue Using a Novel Stable-Isotope Standard and Capture by Anti-Peptide Antibody (SISCAPA) Method.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b04484
Abstract: Acetylation of α-tubulin at Lys-40 is a potential biomarker for cognitive deficits in various neurological disorders. However, this key post-translational modification (PTM) has not been previously studied with mass spectrometry, due to the inadequate distribution… read more here.
Keywords: acetylation; tubulin acetylation; quantitation; method ... See more keywords
Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization
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DOI: 10.1038/s41420-021-00453-9
Abstract: The posttranslational modifications (PTMs) of microtubules have been reported to play an important role in cancer aggressiveness, including apoptosis resistance. In this study, we aimed to investigate the biological role of microtubule PTMs in the… read more here.
Keywords: cancer; tubulin acetylation; lung cancer; paclitaxel ... See more keywords
Dystonin‐A3 upregulation is responsible for maintenance of tubulin acetylation in a less severe dystonia musculorum mouse model for hereditary sensory and autonomic neuropathy type VI
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy250
Abstract: Abstract Hereditary sensory and autonomic neuropathy type VI (HSAN‐VI) is a recessive human disease that arises from mutations in the dystonin gene (DST; also known as Bullous pemphigoid antigen 1 gene). A milder form of… read more here.
Keywords: tubulin acetylation; dst; dstdt tg4; dstdt ... See more keywords
Evodiamine Augments NLRP3 Inflammasome Activation and Anti-bacterial Responses Through Inducing α-Tubulin Acetylation
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00290
Abstract: Evodiamine is a major ingredient of the plant Evodia rutaecarpa, which has long been used for treating infection-related diseases including diarrhea, beriberi and oral ulcer, but the underlying mechanism is unclear. Here we aimed to… read more here.
Keywords: inflammasome activation; tubulin acetylation; activation; nlrp3 inflammasome ... See more keywords