The tubulin code in neuronal polarity
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2018.03.001
Abstract: Cells depend on the asymmetric distribution of their components for homeostasis, differentiation and movement. In no other cell type is this requirement more critical than in the neuron where complex structures are generated during process… read more here.
Keywords: neuronal polarity; tubulin code; code neuronal; tubulin ... See more keywords
Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.09.066
Abstract: Ciliary microtubules (MTs) are extensively decorated with post-translational modifications (PTMs), such as glutamylation of tubulin tails. PTMs and tubulin isotype diversity act as a "tubulin code" that regulates cytoskeletal stability and the activity of MT-associated… read more here.
Keywords: microscopy; tubulin code; function; kinesin ... See more keywords
The Tubulin Code in Microtubule Dynamics and Information Encoding.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.06.008
Abstract: Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton. Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin isoforms and post-translational modifications, a "tubulin code," which is thought to support… read more here.
Keywords: tubulin; tubulin code; microtubule dynamics; code microtubule ... See more keywords
The tubulin code at a glance
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.199471
Abstract: ABSTRACT Microtubules are key cytoskeletal elements of all eukaryotic cells and are assembled of evolutionarily conserved α-tubulin–β-tubulin heterodimers. Despite their uniform structure, microtubules fulfill a large diversity of functions. A regulatory mechanism to control the… read more here.
Keywords: tubulin; code glance; tubulin code; cell science ... See more keywords
Transcriptional, Post-Transcriptional, and Post-Translational Mechanisms Rewrite the Tubulin Code During Cardiac Hypertrophy and Failure
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.837486
Abstract: A proliferated and post-translationally modified microtubule network underlies cellular growth in cardiac hypertrophy and contributes to contractile dysfunction in heart failure. Yet how the heart achieves this modified network is poorly understood. Determining how the… read more here.
Keywords: tubulin code; transcriptional post; failure; heart ... See more keywords
The Tubulin Code and Tubulin-Modifying Enzymes in Autophagy and Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers14010006
Abstract: Simple Summary Microtubules are tubulin polymers that constitute the structure of eukaryotic cells. They control different cell functions that are often deregulated in cancer, such as cell shape, cell motility and the intracellular movement of… read more here.
Keywords: cancer; tubulin; tubulin code; cell ... See more keywords