Bis-nor-diterpene from Cnidoscolus quercifolius (Euphorbiaceae) induces tubulin depolymerization-mediated apoptosis in BRAF-mutated melanoma cells.
Sign Up to like & getrecommendations! Published in 2022 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2022.109849
Abstract: A phytochemical investigation of cytotoxic extract and fractions of Cnidoscolus quercifolius Pohl led to isolation of five terpenoids, including three lupane-type triterpenes (1-3) and two bis-nor-diterpenes (4-5). Compounds 4 (phyllacanthone) and 5 (favelanone) are commonly… read more here.
Keywords: cnidoscolus quercifolius; tubulin depolymerization; melanoma cells; phy ... See more keywords
Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.07.040
Abstract: A series of novel 4-anilinoquinoline derivatives were synthesized and evaluated for their antiproliferative activities. Among them, 14h exhibited the most potent cytotoxic activity with IC50 values ranging from 1.5 to 3.9 nM against all tested cancer… read more here.
Keywords: tubulin depolymerization; anilinoquinoline derivatives; evaluation; design synthesis ... See more keywords