Interactions of β tubulin isotypes with glutathione in differentiated neuroblastoma cells subject to oxidative stress
Sign Up to like & getrecommendations! Published in 2018 at "Cytoskeleton"
DOI: 10.1002/cm.21447
Abstract: Microtubules are a major component of the neuronal cytoskeleton. Tubulin, the subunit protein of microtubules, is an α/β heterodimer. Both α and β exist as families of isotypes, whose members are encoded by different genes… read more here.
Keywords: glutathione differentiated; tubulin isotypes; interactions tubulin; isotypes glutathione ... See more keywords
Alpha‐ and beta‐tubulin isotypes are differentially expressed during brain development
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22745
Abstract: Alpha‐ and beta‐tubulin dimers polymerize into protofilaments that associate laterally to constitute a hollow tube, the microtubule. A dynamic network of interlinking filaments forms the microtubule cytoskeleton, which maintains the structure of cells and is… read more here.
Keywords: tubulin isotypes; tubulin; alpha beta; beta tubulin ... See more keywords
Towards an understanding of the isotype-specific functions of tubulin in neurons: Technical advances in tubulin expression and purification
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Research"
DOI: 10.1016/j.neures.2017.04.002
Abstract: Microtubules are cytoskeletal filaments critical for determining the complex morphology of neurons, as well as the basic architecture and organization of mitosis in all eukaryotic cells. Microtubules in humans are composed of 8 α- and… read more here.
Keywords: tubulin isotypes; towards understanding; expression; isotype specific ... See more keywords
Expression and localization of tubulin isotypes and its mRNAs during Thecaphora frezii developments.
Sign Up to like & getrecommendations! Published in 2022 at "FEMS microbiology ecology"
DOI: 10.1093/femsec/fiac121
Abstract: Thecaphora frezii is a phytopathogenic fungus that infects Arachys hypogaea L. and produces peanut smut. It has three ontological stages teliospores, basidiospores and hyphae. Microtubules are cellular structures that participate in various important cellular processes.… read more here.
Keywords: thecaphora frezii; isotypes mrnas; tubulin isotypes; localization tubulin ... See more keywords
Tubulin isotypes - functional insights from model organisms.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.259539
Abstract: The microtubule cytoskeleton is assembled from the α- and β-tubulin subunits of the canonical tubulin heterodimer, which polymerizes into microtubules, and a small number of other family members, such as γ-tubulin, with specialized functions. Overall,… read more here.
Keywords: tubulin; microtubule function; model organisms; tubulin isotypes ... See more keywords
Interaction of microtubule depolymerizing agent indanocine with different human αβ tubulin isotypes
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0194934
Abstract: Tubulin isotypes are known to regulate the stability and dynamics of microtubules, and are also involved in the development of resistance against microtubule-targeted cancer drugs. Indanocine, a potent microtubule depolymerizing agent, is highly active against… read more here.
Keywords: tubulin isotypes; depolymerizing agent; human tubulin; tubulin ... See more keywords
Microtubules in Microorganisms: How Tubulin Isotypes Contribute to Diverse Cytoskeletal Functions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.913809
Abstract: The cellular functions of the microtubule (MT) cytoskeleton range from relatively simple to amazingly complex. Assembled from tubulin, a heterodimeric protein with α- and β-tubulin subunits, microtubules are long, hollow cylindrical filaments with inherent polarity.… read more here.
Keywords: contribute diverse; tubulin isotypes; microorganisms tubulin; isotypes contribute ... See more keywords
Tubulin Isotypes: Emerging Roles in Defining Cancer Stem Cell Niche
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.876278
Abstract: Although the role of microtubule dynamics in cancer progression is well-established, the roles of tubulin isotypes, their cargos and their specific function in the induction and sustenance of cancer stem cells (CSCs) were poorly explored.… read more here.
Keywords: tubulin; cancer stem; niche; tubulin isotypes ... See more keywords
Possible Roles of Specific Amino Acids in β-Tubulin Isotypes in the Growth and Maintenance of Neurons: Novel Insights From Cephalopod Mollusks
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.838393
Abstract: Microtubules, are formed of the protein tubulin, which is a heterodimer of α- and β-tubulin subunits. Both α- and β-tubulin exist as numerous isotypes, differing in amino acid sequence and tissue distribution. Among the vertebrate… read more here.
Keywords: cephalopod mollusks; growth; tubulin isotypes; iii ... See more keywords
An Emerging Role for Tubulin Isotypes in Modulating Cancer Biology and Chemotherapy Resistance
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18071434
Abstract: Tubulin proteins, as components of the microtubule cytoskeleton perform critical cellular functions throughout all phases of the cell cycle. Altered tubulin isotype composition of microtubules is emerging as a feature of aggressive and treatment refractory… read more here.
Keywords: tubulin isotypes; role tubulin; biology; cancer ... See more keywords