Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
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DOI: 10.1016/j.ejmech.2019.05.072
Abstract: Microtubule is one of the important targets for cancer treatment. A novel class of diaryl substituted imidazo[4,5-c]pyridin-2-ones and imidazo[4,5-c]pyridines were designed based on combination principles by merging the structures of β-lactams and purine-type compounds known… read more here.
Keywords: diaryl substituted; antitumor activities; design synthesis; tubulin katanin ... See more keywords