Tubulin/microtubules as novel clozapine targets
Sign Up to like & getrecommendations! Published in 2021 at "Neuropsychopharmacology Reports"
DOI: 10.1002/npr2.12221
Abstract: Clozapine is currently the only effective drug for treatment‐resistant schizophrenia; nonetheless, its pharmacological mechanism remains unclear, and its administration is limited because of severe adverse effects. By comparing the binding proteins of clozapine and its… read more here.
Keywords: microtubules novel; tubulin microtubules; novel clozapine; clozapine targets ... See more keywords
RDNA-01. TUBULIN AND MICROTUBULES AS MOLECULAR TARGETS FOR TTFIELD THERAPY
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.862
Abstract: TTField (Tumor-treating field) therapy utilizes low intensity intermediate frequency AC electric fields to reduce the spread of cancer. While it has attained FDA approval for the treatment of recurrent glioblastoma multiforme, the exact molecular targets… read more here.
Keywords: tubulin microtubules; ttfield therapy; targets ttfield; rdna tubulin ... See more keywords
The mitotic role of Adenomatous Polyposis Coli requires its bilateral interaction with tubulin and microtubules.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.260152
Abstract: Adenomatous Polyposis Coli (APC) is a scaffold protein with tumour suppressor properties. Mutations causing the loss of its C-terminal domain (APC-C) - bearing cytoskeleton-regulating sequences - correlate with colorectal cancer. The cellular roles of APC… read more here.
Keywords: tubulin microtubules; adenomatous polyposis; bilateral interaction; tubulin ... See more keywords