Understanding molecular mechanisms and predicting phenotypic effects of pathogenic tubulin mutations
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1101/2022.06.16.496400
Abstract: Cells rely heavily on microtubules for several processes, including cell division and molecular trafficking. Mutations in the different tubulin-α and -β proteins that comprise microtubules have been associated with various diseases and are often dominant,… read more here.
Keywords: mechanisms predicting; molecular mechanisms; tubulin mutations; understanding molecular ... See more keywords
Chlamydomonas reinhardtii tubulin-gene disruptants for efficient isolation of strains bearing tubulin mutations
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DOI: 10.1371/journal.pone.0242694
Abstract: The single-cell green alga Chlamydomonas reinhardtii possesses two α-tubulin genes (tua1 and tua2) and two β-tubulin genes (tub1 and tub2), with the two genes in each pair encoding identical amino acid sequences. Here, we screened… read more here.
Keywords: tubulin gene; gene disruptants; tubulin mutations; tubulin ... See more keywords
MAPping tubulin mutations
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1136699
Abstract: Microtubules are filamentous structures that play a critical role in a diverse array of cellular functions including, mitosis, nuclear translocation, trafficking of organelles and cell shape. They are composed of α/β-tubulin heterodimers which are encoded… read more here.
Keywords: disease; mapping tubulin; tubulin mutations; tubulin ... See more keywords