The gamma‐tubulin ring complex: Deciphering the molecular organization and assembly mechanism of a major vertebrate microtubule nucleator
Sign Up to like & getrecommendations! Published in 2021 at "BioEssays"
DOI: 10.1002/bies.202100114
Abstract: Microtubules are protein cylinders with functions in cell motility, signal sensing, cell organization, intracellular transport, and chromosome segregation. One of the key properties of microtubules is their dynamic architecture, allowing them to grow and shrink… read more here.
Keywords: microtubule; tubulin ring; ring complex; organization ... See more keywords
The ring saga: looking back at the discovery of γ-tubulin and γ-tubulin ring complexes
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-07-0290
Abstract: For many years, two central, unanswered questions in cytoskeleton research were how microtubule assembly is nucleated and microtubule polarity established. The discoveries of γ-tubulin and γ-tubulin ring complexes were key advances that allowed these questions… read more here.
Keywords: tubulin ring; ring complexes; discovery tubulin; microtubule ... See more keywords
Reconstitution of the recombinant human γ-tubulin ring complex
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DOI: 10.1098/rsob.200325
Abstract: Cryo-electron microscopy recently resolved the structure of the vertebrate γ-tubulin ring complex (γ-TuRC) purified from Xenopus laevis egg extract and human cells to near-atomic resolution. These studies clarified the arrangement and stoichiometry of γ-TuRC components… read more here.
Keywords: tubulin ring; turc; ring complex; reconstitution recombinant ... See more keywords
The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC)
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.04.11.487887
Abstract: To establish the microtubule cytoskeleton, the cell must tightly regulate when and where microtubules are nucleated. This regulation involves controlling the initial nucleation template, the γ-tubulin ring complex (γTuRC). Although γTuRC is present throughout the… read more here.
Keywords: ring complex; nucleation; tubulin ring; complex turc ... See more keywords
Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase.
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DOI: 10.1126/sciadv.abe0894
Abstract: The microtubule nucleator γ-tubulin ring complex (γTuRC) is essential for the function of microtubule organizing centers such as the centrosome. Since its discovery over two decades ago, γTuRC has evaded in vitro reconstitution and thus… read more here.
Keywords: tubulin ring; turc; ring complex; ruvbl1 ruvbl2 ... See more keywords
A stable core of GCPs 4, 5 and 6 promotes the assembly of γ-tubulin ring complexes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.244368
Abstract: γ-tubulin is a major protein involved in the nucleation of microtubules in all eukaryotes. It forms two different complexes with proteins of the GCP family (gamma-tubulin complex proteins): γ-tubulin small complexes (γTuSCs), containing γ-tubulin and… read more here.
Keywords: gcps; core gcps; tubulin ring; stable core ... See more keywords