Tubulin targeted antimitotic agents based on adamantane lead compound: synthesis, SAR and molecular modeling
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DOI: 10.1016/j.mencom.2020.07.005
Abstract: 5-Hydroxymethyl-2-methoxyphenyl adamantane-1-acetate inhibits cell proliferation and stimulates depolymerization of microtubules of cancer cells to free tubulin. Its analogues were synthesized via the Steglich or Mitsunobu reactions to determine the role of structural subunits of the… read more here.
Keywords: lead compound; targeted antimitotic; antimitotic agents; compound ... See more keywords