Synthetic hydrogels identify matrix physicochemical properties required for renal epithelial cell tubulogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of cell science"
DOI: 10.1242/jcs.226639
Abstract: Synthetic hydrogels with controlled physicochemical matrix properties serve as powerful in vitro tools to dissect cell-extracellular matrix (ECM) interactions that regulate epithelial morphogenesis in 3D microenvironments. In addition, these fully defined matrices overcome the lot-to-lot… read more here.
Keywords: cell; matrix; properties required; epithelial tubulogenesis ... See more keywords
Renal oncometabolite L-2-hydroxyglutarate imposes a block in kidney tubulogenesis: Evidence for an epigenetic basis for the L-2HG-induced impairment of differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.932286
Abstract: 2-Hydroxyglutarate (2HG) overproducing tumors arise in a number of tissues, including the kidney. The tumorigenesis resulting from overproduced 2HG has been attributed to the ability of 2HG alter gene expression by inhibiting α-ketoglutarate (αKG)-dependent dioxygenases,… read more here.
Keywords: tubulogenesis; hydroxyglutarate; kidney; renal oncometabolite ... See more keywords