Hypoxia and Renal Tubulointerstitial Fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8871-2_23
Abstract: Hypoxia, one of the most common causes of kidney injury, is a key pathological condition in various kidney diseases. Renal fibrosis is the terminal pathway involved in the continuous progression of chronic kidney disease (CKD),… read more here.
Keywords: fibrosis; hypoxia renal; biology; tubulointerstitial fibrosis ... See more keywords
Tubulointerstitial fibrosis can sensitize the kidney to subsequent glomerular injury.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2017.04.010
Abstract: Chronic glomerular injury is associated with eventual development of tubulointerstitial fibrosis. Here we aimed to assess whether, and how, mild chronic tubulointerstitial injury affects glomeruli. For this, we generated mice expressing different toxin receptors, one… read more here.
Keywords: dtr; nep25 dtr; tubulointerstitial fibrosis; injury ... See more keywords
The C5a/C5aR1 axis promotes progression of renal tubulointerstitial fibrosis in a mouse model of renal ischemia/reperfusion injury.
Sign Up to like & getrecommendations! Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2019.01.039
Abstract: C5a is a potent proinflammatory agonist that mediates renal ischemia reperfusion (IR) injury, but the potential for modulating chronic post-ischemic fibrosis and use of therapeutic antagonist are undefined. Here we determine whether C5a receptor 1… read more here.
Keywords: renal ischemia; c5a; fibrosis; c5ar1 ... See more keywords
A novel role of LRP5 in tubulointerstitial fibrosis through activating TGF-β/Smad signaling
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-0142-x
Abstract: Previous studies by us and others demonstrated that activation of Wnt/β-catenin signaling plays a pathogenic role in chronic kidney diseases (CKD). Wnt co-receptor LRP5 variants are reported to associate with autosomal dominant polycystic kidney disease;… read more here.
Keywords: tgf smad; smad signaling; role; tubulointerstitial fibrosis ... See more keywords
Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-95827-5
Abstract: This study aimed at comparing the effects of metformin on tubulointerstitial fibrosis (TIF) in different stages of diabetic nephropathy (DN) in vivo and evaluating the mechanism in high glucose (HG)-treated renal tubular epithelial cells (RTECs)… read more here.
Keywords: fibrosis; metformin; metformin attenuates; attenuates renal ... See more keywords
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical science"
DOI: 10.1042/cs20200171
Abstract: Hyperglycemia-induced renal epithelial to mesenchymal transition (EMT) is a key pathological factor in diabetic renal tubulointerstitial fibrosis (RIF). Our previous studies have shown that connexin 43 (Cx43) activation attenuated the development of diabetic renal fibrosis.… read more here.
Keywords: hif; renal tubulointerstitial; diabetic renal; tubulointerstitial fibrosis ... See more keywords
miR-382 Contributes to Renal Tubulointerstitial Fibrosis by Downregulating HSPD1
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/4708516
Abstract: Redox imbalance plays an important role in the pathogenesis of CKD progression. Previously, we demonstrated that microRNA-382 (miR-382) contributed to TGF-β1-induced loss of epithelial polarity in human kidney epithelial cells, but its role in the… read more here.
Keywords: mir 382; mir; tubulointerstitial fibrosis; hspd1 ... See more keywords
Dapagliflozin Attenuates Renal Tubulointerstitial Fibrosis Associated With Type 1 Diabetes by Regulating STAT1/TGFβ1 Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00441
Abstract: Tubulointerstitial fibrosis (TIF) plays an important role in the progression of renal fibrosis in diabetic nephropathy (DN). Accumulating evidence supports a crucial inhibitory effect of dapagliflozin, a SGLT2 inhibitor, on TIF, but the underlying mechanisms… read more here.
Keywords: tubulointerstitial fibrosis; dapagliflozin attenuates; stat1 tgf; fibrosis ... See more keywords
circHIPK3 Exacerbates Folic Acid-Induced Renal Tubulointerstitial Fibrosis by Sponging miR-30a
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.715567
Abstract: Renal tubulointerstitial fibrosis is a common pathological feature of progressive chronic kidney disease (CKD), and current treatment has limited efficacy. The circular RNA circHIPK3 is reported to participate in the pathogenesis of various human diseases.… read more here.
Keywords: renal fibrosis; circhipk3; mir 30a; tubulointerstitial fibrosis ... See more keywords
The System Profile of Renal Drug Transporters in Tubulointerstitial Fibrosis Model and Consequent Effect on Pharmacokinetics
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DOI: 10.3390/molecules27030704
Abstract: With the widespread clinical use of drug combinations, the incidence of drug–drug interactions (DDI) has significantly increased, accompanied by a variety of adverse reactions. Drug transporters play an important role in the development of DDI… read more here.
Keywords: drug transporters; correlation; tubulointerstitial fibrosis; drug ... See more keywords
Evaluation of TGF-β1 and MCP-1 expression and tubulointerstitial fibrosis in children with Henoch-Schönlein purpura nephritis and IgA nephropathy: A clinical correlation
Sign Up to like & getrecommendations! Published in 2017 at "Clinics"
DOI: 10.6061/clinics/2017(02)05
Abstract: OBJECTIVES: Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are two diseases with similar clinical presentations but very different prognoses. Transforming growth factor β1 and monocyte chemoattractant protein-1 have been associated with the development of tissue… read more here.
Keywords: henoch sch; fibrosis; nlein purpura; tubulointerstitial fibrosis ... See more keywords