The extent of tubulointerstitial inflammation is an independent predictor of renal survival in lupus nephritis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Nephrology"
DOI: 10.1007/s40620-021-01007-z
Abstract: Lupus nephritis (LN) is a major complication in patients with systemic lupus erythematosus (SLE). Tubulointerstitial injury is an inflammatory process that, if not attenuated, can promote renal damage. Despite this, the current 2003 ISN/RPS “glomerulocentric”… read more here.
Keywords: fibrosis tubular; interstitial fibrosis; inflammation; renal survival ... See more keywords
Machine Learning to Quantify In Situ Humoral Selection in Human Lupus Tubulointerstitial Inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.593177
Abstract: In human lupus nephritis, tubulointerstitial inflammation (TII) is associated with in situ expansion of B cells expressing anti-vimentin antibodies (AVAs). The mechanism by which AVAs are selected is unclear. Herein, we demonstrate that AVA somatic… read more here.
Keywords: machine learning; affinity; selection; tubulointerstitial inflammation ... See more keywords