P16INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency
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DOI: 10.1038/s41598-017-06868-8
Abstract: To determine whether p16INK4a deletion ameliorated renal tubulointerstitial injury by inhibiting a senescence-associated secretory phenotype (SASP) in Bmi-1-deficient (Bmi-1−/−) mice, renal phenotypes were compared among 5-week-old Bmi-1 and p16INK4a double-knockout, and Bmi-1−/− and wild-type mice.… read more here.
Keywords: tubulointerstitial injury; bmi; senescence; p16ink4a deletion ... See more keywords
Gene-Based Network Analysis Reveals Prognostic Biomarkers Implicated in Diabetic Tubulointerstitial Injury
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DOI: 10.1155/2022/2700392
Abstract: Background Diabetic nephropathy (DN), a significant cause of chronic kidney disease (CKD), is a devastating disease worldwide. Objective The aim of this study was to reveal crucial genes closely linked to the molecular mechanism of… read more here.
Keywords: hub genes; network; tubulointerstitial injury; network analysis ... See more keywords
Activation of Complement Pathways in Kidney Tissue May Mediate Tubulointerstitial Injury in Diabetic Nephropathy
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DOI: 10.3389/fmed.2022.845679
Abstract: Introduction Key genes involved in tubulointerstitial injury may influence the development and progression of diabetic nephropathy (DN). We investigated whether complement-related genes are linked to the mechanism underlying tubulointerstitial injury in DN. Methods We analyzed… read more here.
Keywords: complement; expression; tubulointerstitial injury; injury ... See more keywords