Tauroursodeoxycholic acid attenuates cisplatin-induced ototoxicity by inhibiting the accumulation and aggregation of unfolded or misfolded proteins in the endoplasmic reticulum.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152736
Abstract: Cisplatin-induced ototoxicity is one of the important reasons that limit the drug's clinical application, and its mechanism has not been fully elucidated so far. The aim of this study was to explore the attenuate effect… read more here.
Keywords: aggregation; tudca; cisplatin; induced ototoxicity ... See more keywords
Tauroursodeoxycholic acid attenuates gentamicin-induced cochlear hair cell death in vitro.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.05.007
Abstract: Gentamycin is one of the most clinically used aminoglycoside antibiotics which induce intrinsic apoptosis of hair cells. Tauroursodeoxycholic acid (TUDCA) is known as safe cell-protective agent in disorders associated with apoptosis. We aimed to investigate… read more here.
Keywords: tudca; gentamicin induced; cell; hair cell ... See more keywords
Co-immobilised 7α- and 7β-HSDH as recyclable biocatalyst: high-performance production of TUDCA from waste chicken bile
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra06798h
Abstract: Chicken gallbladder has long been considered to be worthless and discarded as waste. The main composition of chicken bile is taurochenodeoxycholic acid (TCDCA), which is the isomeride of tauroursodeoxycholic acid (TUDCA). TUDCA has been effectively… read more here.
Keywords: tudca; waste; recyclable biocatalyst; chicken bile ... See more keywords
Tauroursodeoxycholic acid (TUDCA) counters osteoarthritis by regulating intracellular cholesterol levels and membrane fluidity of degenerated chondrocytes.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c9bm00426b
Abstract: Cholesterol and lipid metabolism are associated with osteoarthritis (OA) in human cartilage. High cholesterol levels in OA chondrocytes leads to decreased membrane fluidity and blocks the signaling cascade associated with the expression of chondrogenic genes.… read more here.
Keywords: cholesterol levels; tudca; membrane fluidity; cholesterol ... See more keywords
Effect of acute tauroursodeoxycholic acid ingestion on microvascular function in men and women
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5729379
Abstract: The endoplasmic reticulum is a multipurpose organelle found in most human cells, including endothelial and smooth muscle cells of blood vessels. It plays a key role in posttranslational folding of new proteins and reprocessing of… read more here.
Keywords: ingestion; tudca; men women; physiology ... See more keywords
TUDCA treatment restores anticontractile function of perivascular adipose tissue (PVAT) in post-weaning protein-restricted mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734578
Abstract: Healthy perivascular adipose tissue (PVAT) has anticontractile, anti-inflammatory and antioxidant actions that can be disrupted by cardiometabolic risk factors. In the present study we hypothesized that protein restriction in the early phases of development could… read more here.
Keywords: tudca; pvat; expression; physiology ... See more keywords
The effect of tauroursodeoxycholic Acid (TUDCA) treatment on placental endoplasmic reticulum (ER) stress in a rat model of advanced maternal age
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0282442
Abstract: Advanced maternal age (≥35 years) is associated with an increased risk of pregnancy complications such as fetal growth restriction and preeclampsia. We previously demonstrated poor pregnancy outcomes (reduced fetal body weight), altered vascular function, and… read more here.
Keywords: stress; tudca; advanced maternal; maternal age ... See more keywords
Repair effect of the poly (D,L-lactic acid) nanoparticle containing tauroursodeoxycholic acid-eluting stents on endothelial injury after stent implantation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1025558
Abstract: Background Chronic endoplasmic reticulum stress (ERS) plays a crucial role in cardiovascular diseases. Thus, it can be considered a therapeutic target for these diseases. In this study, poly (D,L-lactic acid) (PDLLA) nanoparticle-eluting stents loaded with… read more here.
Keywords: tudca; poly lactic; eluting stents; acid ... See more keywords
Tauroursodeoxycholic Acid Reduces Neuroinflammation but Does Not Support Long Term Functional Recovery of Rats with Spinal Cord Injury
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10071501
Abstract: The bile acid tauroursodeoxycholic acid (TUDCA) reduces cell death under oxidative stress and inflammation. Implants of bone marrow-derived stromal cells (bmSC) are currently under investigation in clinical trials of spinal cord injury (SCI). Since cell… read more here.
Keywords: tudca; tauroursodeoxycholic acid; injury; spinal cord ... See more keywords