The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.06.037
Abstract: The intestinal response to helminth infection is mediated by a recently established type 2 immune circuit that consists of intestinal tuft cells and type 2 innate lymphoid cells (ILC2s). Schneider et al. have discovered that tuft… read more here.
Keywords: tuft; circuit; cell ilc2; tuft cell ... See more keywords
Tuft cells: From the mucosa to the thymus.
Sign Up to like & getrecommendations! Published in 2019 at "Immunology letters"
DOI: 10.1016/j.imlet.2019.02.003
Abstract: Tuft cells are epithelial chemosensory cells with unique morphological and molecular characteristics, the most noticeable of which is a tuft of long and thick microvilli on their apical side, as well as expression of a… read more here.
Keywords: tuft cells; cells mucosa; tuft; mucosa thymus ... See more keywords
A Tuft Act to Follow: Leukotrienes Take the Stage in Anti-worm Immunity.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.02.011
Abstract: Tuft cells are specialized taste-chemosensory cells that detect the presence of intestinal parasites and orchestrate type 2 immunity. In this issue of Immunity, McGinty et al. discover that parasitic worms, but not commensal protists, stimulate tuft… read more here.
Keywords: immunity; act follow; tuft; tuft act ... See more keywords
Mouse intestinal tuft cells express advillin but not villin
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-65469-0
Abstract: Tuft (or brush) cells are solitary chemosensory cells scattered throughout the epithelia of the respiratory and alimentary tract. The actin-binding protein villin (Vil1) is used as a marker of tuft cells and the villin promoter… read more here.
Keywords: tuft cells; villin; tuft; expression ... See more keywords
The stochastic nature of action potential backpropagation in apical tuft dendrites.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of neurophysiology"
DOI: 10.1152/jn.00800.2016
Abstract: In cortical pyramidal neurons, backpropagating action potentials (bAPs) supply Ca2+ to synaptic contacts on dendrites. To determine whether the efficacy of AP backpropagation into apical tuft dendrites is stable over time, we performed dendritic Ca2+… read more here.
Keywords: voltage; backpropagation apical; bap ca2; tuft ... See more keywords
Adolescent is more susceptible to tuft cell hyperplasia with increased mast cell infiltration and enhanced FFA2/5-HT mediated anion secretion in mouse duodenum and jejunum
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731366
Abstract: Though one of the primary functions of intestinal tuft cells us the sensing of the luminal content, the contribution of tuft cells to epithelial secretion has not been previously studied. We have found that in… read more here.
Keywords: cell; tuft cell; physiology; tuft ... See more keywords
Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.78217
Abstract: Viral infection often causes severe damage to the lungs, leading to the appearance of ectopic basal cells (EBCs) and tuft cells in the lung parenchyma. Thus far, the roles of these ectopic epithelial cells in… read more here.
Keywords: cells alveolar; trp63creert2; alveolar regeneration; tuft ... See more keywords
Deoxycholic acid exacerbates intestinal inflammation by modulating interleukin-1β expression and tuft cell proportion in dextran sulfate sodium-induced murine colitis
Sign Up to like & getrecommendations! Published in 2023 at "PeerJ"
DOI: 10.7717/peerj.14842
Abstract: Background The etiology of inflammatory bowel disease (IBD) remains unclear. However, intestinal metabolism is known to be critical in the pathogenesis of IBD. Bile acid is one of the main intestinal metabolites, and its role… read more here.
Keywords: ibd; deoxycholic acid; colitis; tuft ... See more keywords