The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.06.037
Abstract: The intestinal response to helminth infection is mediated by a recently established type 2 immune circuit that consists of intestinal tuft cells and type 2 innate lymphoid cells (ILC2s). Schneider et al. have discovered that tuft… read more here.
Keywords: tuft; circuit; cell ilc2; tuft cell ... See more keywords
Tuft cells: From the mucosa to the thymus.
Sign Up to like & getrecommendations! Published in 2019 at "Immunology letters"
DOI: 10.1016/j.imlet.2019.02.003
Abstract: Tuft cells are epithelial chemosensory cells with unique morphological and molecular characteristics, the most noticeable of which is a tuft of long and thick microvilli on their apical side, as well as expression of a… read more here.
Keywords: tuft cells; cells mucosa; tuft; mucosa thymus ... See more keywords
A Tuft Act to Follow: Leukotrienes Take the Stage in Anti-worm Immunity.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.02.011
Abstract: Tuft cells are specialized taste-chemosensory cells that detect the presence of intestinal parasites and orchestrate type 2 immunity. In this issue of Immunity, McGinty et al. discover that parasitic worms, but not commensal protists, stimulate tuft… read more here.
Keywords: immunity; act follow; tuft; tuft act ... See more keywords
Intestinal tuft cell subtypes represent successive stages of maturation driven by crypt-villus signaling gradients
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-61878-9
Abstract: Intestinal tuft cells are epithelial sentinels that trigger host defense upon detection of parasite-derived compounds. While they represent potent targets for immunomodulatory therapies in inflammation-driven intestinal diseases, their functioning and differentiation are poorly understood. Here,… read more here.
Keywords: maturation; crypt villus; tuft; intestinal tuft ... See more keywords
Tuft cells act as regenerative stem cells in the human intestine
Sign Up to like & getrecommendations! Published in 2024 at "Nature"
DOI: 10.1038/s41586-024-07952-6
Abstract: In mice, intestinal tuft cells have been described as a long-lived, postmitotic cell type. Two distinct subsets have been identified: tuft-1 and tuft-2 (ref. 1). By combining analysis of primary human intestinal resection material and… read more here.
Keywords: tuft cells; tuft; stem cells; tuft cell ... See more keywords
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation
Sign Up to like & getrecommendations! Published in 2025 at "Nature Immunology"
DOI: 10.1038/s41590-025-02104-y
Abstract: The tuft cell–group 2 innate lymphoid cell (ILC2) circuit orchestrates rapid type 2 responses upon detecting microbially derived succinate and luminal helminths. Our findings delineate key mechanistic steps involving IP3R2 engagement and Ca2+ flux, governing… read more here.
Keywords: cell 17rb; tuft; cell; tuft cell ... See more keywords
Mouse intestinal tuft cells express advillin but not villin
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-65469-0
Abstract: Tuft (or brush) cells are solitary chemosensory cells scattered throughout the epithelia of the respiratory and alimentary tract. The actin-binding protein villin (Vil1) is used as a marker of tuft cells and the villin promoter… read more here.
Keywords: tuft cells; villin; tuft; expression ... See more keywords
The stochastic nature of action potential backpropagation in apical tuft dendrites.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of neurophysiology"
DOI: 10.1152/jn.00800.2016
Abstract: In cortical pyramidal neurons, backpropagating action potentials (bAPs) supply Ca2+ to synaptic contacts on dendrites. To determine whether the efficacy of AP backpropagation into apical tuft dendrites is stable over time, we performed dendritic Ca2+… read more here.
Keywords: voltage; backpropagation apical; bap ca2; tuft ... See more keywords
Adolescent is more susceptible to tuft cell hyperplasia with increased mast cell infiltration and enhanced FFA2/5-HT mediated anion secretion in mouse duodenum and jejunum
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731366
Abstract: Though one of the primary functions of intestinal tuft cells us the sensing of the luminal content, the contribution of tuft cells to epithelial secretion has not been previously studied. We have found that in… read more here.
Keywords: cell; tuft cell; physiology; tuft ... See more keywords
Enteric tuft cells coordinate timely expulsion of the tapeworm Hymenolepis diminuta from the murine host by coordinating local but not systemic immunity
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1012381
Abstract: Recognizing that enteric tuft cells can signal the presence of nematode parasites, we investigated whether tuft cells are required for the expulsion of the cestode, Hymenolepis diminuta, from the non-permissive mouse host, and in concomitant… read more here.
Keywords: immunity; enteric tuft; tuft; expulsion ... See more keywords
Acute tuft cell ablation in mice induces malabsorption and alterations in secretory and immune cell lineages in the small intestine
Sign Up to like & getrecommendations! Published in 2025 at "Physiological Reports"
DOI: 10.14814/phy2.70264
Abstract: Intestinal tuft cells have recently been the focus of many studies due to their function in chemosensation and type 2 immunity in human gastrointestinal diseases. This study investigated the impact of acute tuft cell loss… read more here.
Keywords: mice; acute tuft; tuft; cell ... See more keywords