The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.06.037
Abstract: The intestinal response to helminth infection is mediated by a recently established type 2 immune circuit that consists of intestinal tuft cells and type 2 innate lymphoid cells (ILC2s). Schneider et al. have discovered that tuft… read more here.
Keywords: tuft; circuit; cell ilc2; tuft cell ... See more keywords
Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.01.051
Abstract: Although enteric helminth infections modulate immunity to mucosal pathogens, their effects on systemic microbes remain less established. Here, we observe increased mortality in mice coinfected with the enteric helminth Heligmosomoides polygyrus bakeri (Hpb) and West… read more here.
Keywords: coinfection; susceptibility; enteric helminth; receptor ... See more keywords
Helminths get MIFfed by the tuft cell – ILC2 circuit
Sign Up to like & getrecommendations! Published in 2022 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12544
Abstract: The gut is a common site for helminth infections. Immunity to helminths relies on a strong type 2 response that is characterized by cytokines such as interleukin (IL)-4, 5 and 13. Intestinal type 2 immunity… read more here.
Keywords: helminths get; cell; get miffed; tuft cell ... See more keywords
Adolescent is more susceptible to tuft cell hyperplasia with increased mast cell infiltration and enhanced FFA2/5-HT mediated anion secretion in mouse duodenum and jejunum
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731366
Abstract: Though one of the primary functions of intestinal tuft cells us the sensing of the luminal content, the contribution of tuft cells to epithelial secretion has not been previously studied. We have found that in… read more here.
Keywords: cell; tuft cell; physiology; tuft ... See more keywords
Alteration of secretory cell lineages and immune cell migration induced by acute tuft cell ablation in mouse intestine
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731698
Abstract: Background: Intestinal tuft cells have only been recently investigated thoroughly due to their roles in type 2 immunity and chemosensory function. This rare population of intestinal epithelium is implicated in extensively interacting with other cell… read more here.
Keywords: cell; day; mouse; tuft cell ... See more keywords
Novel protocol to observe the intestinal tuft cell using transmission electron microscopy
Sign Up to like & getrecommendations! Published in 2022 at "Biology Open"
DOI: 10.1242/bio.059007
Abstract: ABSTRACT The tuft cell is a chemosensory cell, a specific cell type sharing the taste transduction system with a taste cell on the tongue, of which the existence has been discovered in various tissues including… read more here.
Keywords: cell; electron microscopy; microscopy; tuft cell ... See more keywords