Tuft cells: From the mucosa to the thymus.
Sign Up to like & getrecommendations! Published in 2019 at "Immunology letters"
DOI: 10.1016/j.imlet.2019.02.003
Abstract: Tuft cells are epithelial chemosensory cells with unique morphological and molecular characteristics, the most noticeable of which is a tuft of long and thick microvilli on their apical side, as well as expression of a… read more here.
Keywords: tuft cells; cells mucosa; tuft; mucosa thymus ... See more keywords
Mouse intestinal tuft cells express advillin but not villin
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-65469-0
Abstract: Tuft (or brush) cells are solitary chemosensory cells scattered throughout the epithelia of the respiratory and alimentary tract. The actin-binding protein villin (Vil1) is used as a marker of tuft cells and the villin promoter… read more here.
Keywords: tuft cells; villin; tuft; expression ... See more keywords
Aiding and abetting norovirus disease
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.360.6385.166-e
Abstract: Norovirus Norovirus is highly infectious and usually causes transient, acute disease. In some individuals, norovirus persists and is associated with inflammatory bowel disorders. While investigating the cell tropism for murine norovirus, Wilen et al. discovered… read more here.
Keywords: tuft cells; aiding abetting; norovirus disease; disease ... See more keywords
IL-13–programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.159832
Abstract: Chronic type 2 (T2) inflammatory diseases of the respiratory tract are characterized by mucus overproduction and disordered mucociliary function, which are largely attributed to the effects of IL-13 on common epithelial cell types (mucus secretory… read more here.
Keywords: airway tuft; mucociliary function; tuft cells; cftr dependent ... See more keywords
Short-term high fat feeding induces inflammatory responses of tuft cells and mucosal barrier cells in the murine stomach.
Sign Up to like & getrecommendations! Published in 2022 at "Histology and histopathology"
DOI: 10.14670/hh-18-503
Abstract: Feeding mice with a high fat diet (HFD) induces inflammation and results in changes of gene expression and cellular composition in various tissues throughout the body, including the gastrointestinal tract. In the stomach, tuft cells… read more here.
Keywords: inflammatory responses; tuft cells; high fat; stomach ... See more keywords
An update on the biological characteristics and functions of tuft cells in the gut
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1102978
Abstract: The intestine is a powerful digestive system and one of the most sophisticated immunological organs. Evidence shows that tuft cells (TCs), a kind of epithelial cell with distinct morphological characteristics, play a significant role in… read more here.
Keywords: characteristics functions; update biological; cells gut; functions tuft ... See more keywords
The critical roles and therapeutic implications of tuft cells in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1047188
Abstract: Tuft cells are solitary chemosensory epithelial cells with microvilli at the top, which are found in hollow organs such as the gastrointestinal tract, pancreas, and lungs. Recently, an increasing number of studies have revealed the… read more here.
Keywords: tuft cells; implications tuft; cells cancer; therapeutic implications ... See more keywords
Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.78217
Abstract: Viral infection often causes severe damage to the lungs, leading to the appearance of ectopic basal cells (EBCs) and tuft cells in the lung parenchyma. Thus far, the roles of these ectopic epithelial cells in… read more here.
Keywords: cells alveolar; trp63creert2; alveolar regeneration; tuft ... See more keywords